Immunology Antibodies 3
Anti-Phospho-Lyn-Y396 Antibody (CABP1050)
- SKU:
- CABP1050
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Phospho-Lyn-Y396 Antibody | 
| Antibody SKU: | CABP1050 | 
| Antibody Size: | 20uL, 50uL, 100uL | 
| Application: | WB | 
| Reactivity: | Human, Mouse, Rat | 
| Host Species: | Rabbit | 
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y396 of human Lyn | 
| Application: | WB | 
| Recommended Dilution: | WB 1:500 - 1:2000 | 
| Reactivity: | Human, Mouse, Rat | 
| Positive Samples: | NIH/3T3 | 
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y396 of human Lyn | 
| Purification Method: | Affinity purification | 
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. | 
| Isotype: | IgG | 
| Sequence: | Email for sequence | 
| Gene ID: | 4067 | 
| Uniprot: | P07948 | 
| Cellular Location: | |
| Calculated MW: | 56kDa | 
| Observed MW: | 56KDa | 
| Synonyms: | JTK8, p53Lyn, p56Lyn | 
| Background: | This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] | 
| UniProt Protein Function: | LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. | 
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (non-receptor); Kinase, protein; Oncoprotein; Protein kinase, TK; EC 2.7.10.2; TK group; Src family Chromosomal Location of Human Ortholog: 8q13 Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi apparatus; lipid raft; mast cell granule; mitochondrial crista; mitochondrial intermembrane space; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density Molecular Function:ATP binding; enzyme binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; protein binding; protein-tyrosine kinase activity; receptor binding; receptor signaling protein tyrosine kinase activity; SH3 domain binding; ubiquitin protein ligase binding Biological Process: adaptive immune response; axon guidance; B cell homeostasis; B cell receptor signaling pathway; blood coagulation; cellular response to extracellular stimulus; cytokine secretion; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of immune response; negative regulation of MAP kinase activity; negative regulation of myeloid leukocyte differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neurite development; oligodendrocyte development; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to amino acid stimulus; response to axon injury; response to carbohydrate stimulus; response to DNA damage stimulus; response to drug; response to hormone stimulus; response to insulin stimulus; response to organic cyclic substance; response to sterol depletion; response to toxin; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction | 
| NCBI Summary: | This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] | 
| UniProt Code: | P07948 | 
| NCBI GenInfo Identifier: | 125480 | 
| NCBI Gene ID: | 4067 | 
| NCBI Accession: | P07948.3 | 
| UniProt Secondary Accession: | P07948,A0AVQ5, | 
| UniProt Related Accession: | P07948 | 
| Molecular Weight: | 56,033 Da | 
| NCBI Full Name: | Tyrosine-protein kinase Lyn | 
| NCBI Synonym Full Names: | LYN proto-oncogene, Src family tyrosine kinase | 
| NCBI Official Symbol: | LYNÂ Â | 
| NCBI Official Synonym Symbols: | JTK8; p53Lyn; p56Lyn  | 
| NCBI Protein Information: | tyrosine-protein kinase Lyn | 
| UniProt Protein Name: | Tyrosine-protein kinase Lyn | 
| UniProt Synonym Protein Names: | Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn | 
| Protein Family: | Tyrosine-protein kinase | 
| UniProt Gene Name: | LYNÂ Â | 
| UniProt Entry Name: | LYN_HUMAN | 
 
 
            
 
             
             
             
            