Cell Biology Antibodies 16
Anti-Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 Antibody (CABP0472)
- SKU:
- CABP0472
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 Antibody |
Antibody SKU: | CABP0472 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IP |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic phosphorylated peptide around T185/Y187 of human ERK2 (NP_002736.3). |
Application: | WB IHC IP |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IP 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | Jurkat, NIH/3T3, C6 |
Immunogen: | A synthetic phosphorylated peptide around T185/Y187 of human ERK2 (NP_002736.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | FLTE YVA |
Gene ID: | 5594/5595 |
Uniprot: | P28482/P27361 |
Cellular Location: | |
Calculated MW: | 36kDa/41kDa/38kDa/40kDa/43kDa |
Observed MW: | 42KDa/44KDa |
Synonyms: | MAPK1/MAPK3 |
Background: | This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] |