Cell Cycle Antibodies 2
Anti-Phospho-CDC25A-S76 Antibody (CABP1166)
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- SKU:
- CABP1166
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-Phospho-CDC25A-S76 Antibody |
| Antibody SKU: | CABP1166 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S76 of human CDC25A |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S76 of human CDC25A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 993 |
| Uniprot: | P30304 |
| Cellular Location: | |
| Calculated MW: | 54kDa/59kDa |
| Observed MW: | 59kDa |
 | Western blot - Phospho-CDC25A-S76 Rabbit pAb (CABP1166) |
| Synonyms: | CDC25A, CDC25A2 |
| Background: | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CDC25A: a member of the MPI phosphatase family. Functions as a dosage-dependent inducer in mitotic control. Required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p21 Cellular Component: nucleoplasm; cytosol Molecular Function:protein binding; protein tyrosine phosphatase activity; protein kinase binding Biological Process: cell proliferation; mitosis; response to radiation; cell division; regulation of cell cycle; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; DNA replication; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle |
| NCBI Summary: | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30304 |
| NCBI GenInfo Identifier: | 50403734 |
| NCBI Gene ID: | 993 |
| NCBI Accession: | P30304.2 |
| UniProt Secondary Accession: | P30304,Q8IZH5, Q96IL3, Q9H2F2, |
| UniProt Related Accession: | P30304 |
| Molecular Weight: | |
| NCBI Full Name: | M-phase inducer phosphatase 1 |
| NCBI Synonym Full Names: | cell division cycle 25A |
| NCBI Official Symbol: | CDC25A |
| NCBI Official Synonym Symbols: | CDC25A2 |
| NCBI Protein Information: | M-phase inducer phosphatase 1; CDC25A2-CAG isoform; CDC25 isoform A1-CAG; dual specificity phosphatase CDC25A |
| UniProt Protein Name: | M-phase inducer phosphatase 1 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase Cdc25A |
| Protein Family: | M-phase inducer phosphatase |
| UniProt Gene Name: | CDC25A |
| UniProt Entry Name: | MPIP1_HUMAN |
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