Immunology Antibodies 3
Anti-Phospho-Btk-Y223 Antibody (CABP0100)
- SKU:
- CABP0100
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Phospho-Btk-Y223 Antibody |
| Antibody SKU: | CABP0100 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around Y223 of human Btk (NP_000052.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic phosphorylated peptide around Y223 of human Btk (NP_000052.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALYD Y |
| Gene ID: | 695 |
| Uniprot: | Q06187 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
| Calculated MW: | 76kDa/79kDa |
| Observed MW: | Refer to Figures |
 | Immunofluorescence analysis of U2OS cells using Phospho-Btk-Y223 antibody (CABP0100). Blue: DAPI for nuclear staining. |
| Synonyms: | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, BTK |
| Background: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Tec family Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; mast cell granule; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:ATP binding; identical protein binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity Biological Process: adaptive immune response; apoptosis; cell maturation; histamine secretion by mast cell; I-kappaB kinase/NF-kappaB cascade; immune system process; innate immune response; negative regulation of cytokine production; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription, DNA-dependent; response to organic substance; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q06187 |
| NCBI GenInfo Identifier: | 547759 |
| NCBI Gene ID: | 695 |
| NCBI Accession: | Q06187.3 |
| UniProt Secondary Accession: | Q06187,Q61365, |
| UniProt Related Accession: | Q06187 |
| Molecular Weight: | |
| NCBI Full Name: | Tyrosine-protein kinase BTK |
| NCBI Synonym Full Names: | Bruton tyrosine kinase |
| NCBI Official Symbol: | BTK |
| NCBI Official Synonym Symbols: | AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1 |
| NCBI Protein Information: | tyrosine-protein kinase BTK |
| UniProt Protein Name: | Tyrosine-protein kinase BTK |
| UniProt Synonym Protein Names: | Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; Kinase EMB |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | Btk |
| UniProt Entry Name: | BTK_MOUSE |
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