Signal Transduction Antibodies 3
Anti-Phosducin Antibody (CAB8447)
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- SKU:
- CAB8447
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Phosducin Antibody |
| Antibody SKU: | CAB8447 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PDC (NP_002588.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, 22Rv1, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PDC (NP_002588.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEA KSQS LEED FEGQ ATHT GPKG VIND WRKF KLES QDSD SIPP SKKE ILRQ MSSP QSRN GKDS KERV SRKM SIQE YELI HKEK EDEN CLRK YRRQ CMQD MHQK LSFG PRYG FVYE LETG KQFL ETIE KELK ITTI VVHI YEDG IKGC DALN SSLT CLAA EYPI VKFC KIKA SNTG AGDR FSLD VLPT LLIY KGGE LISN FISV AEQF AEEF FAGD VESF LNEY GLLP EREV HVLE HTKI EEED VE |
| Gene ID: | 5132 |
| Uniprot: | P20941 |
| Cellular Location: | Cell projection, Cytoplasm, Nucleus, Nucleus, Photoreceptor inner segment, cilium, cytosol, photoreceptor outer segment |
| Calculated MW: | 22kDa/28kDa/32kDa |
| Observed MW: | 36kDa |
| Synonyms: | PDC, MEKA, PHD, PhLOP, PhLP, phosducin |
| Background: | This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | phosducin: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. Belongs to the phosducin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 1q25.2 Cellular Component: cytoplasm Molecular Function:phospholipase inhibitor activity; queuine tRNA-ribosyltransferase activity Biological Process: G-protein coupled receptor protein signaling pathway; phototransduction; queuosine biosynthetic process |
| NCBI Summary: | This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20941 |
| NCBI GenInfo Identifier: | 130134 |
| NCBI Gene ID: | 5132 |
| NCBI Accession: | P20941.1 |
| UniProt Secondary Accession: | P20941,Q14816, Q9UP22, Q9UP23, |
| UniProt Related Accession: | P20941 |
| Molecular Weight: | 32,118 Da |
| NCBI Full Name: | Phosducin |
| NCBI Synonym Full Names: | phosducin |
| NCBI Official Symbol: | PDC |
| NCBI Official Synonym Symbols: | PHD; MEKA; PhLP; PhLOP |
| NCBI Protein Information: | phosducin |
| UniProt Protein Name: | Phosducin |
| UniProt Synonym Protein Names: | 33 kDa phototransducing protein; Protein MEKA |
| Protein Family: | Phosducin |
| UniProt Gene Name: | PDC |
| UniProt Entry Name: | PHOS_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDC antibody (CAB8447) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat retina using PDC antibody (CAB8447) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse retina using PDC antibody (CAB8447) at dilution of 1:200 (40x lens). |
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