Anti-Periostin Antibody (CAB9009)

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SKU:
CAB9009
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
OSF-2
Synonyms:
OSF2
Synonyms:
PDLPOSTN
Synonyms:
PN
Research Area:
Cell Biology

Description

Product Name:Periostin Rabbit mAb
Product Code:CAB9009
Size:20uL, 50uL, 100uL
Synonyms:OSF-2, OSF2, PDLPOSTN, PN
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Periostin
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:A synthesized peptide derived from human Periostin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10631
Uniprot:Q15063
Calculated MW:85kDa
Observed MW:80KDa
UniProt Protein Function:POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; trans-Golgi network

Molecular Function:heparin binding; protein binding; cell adhesion molecule binding

Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development

NCBI Summary:This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
UniProt Code:Q15063
NCBI GenInfo Identifier:93138709
NCBI Gene ID:10631
NCBI Accession:Q15063.2
UniProt Secondary Accession:Q15063,Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9, B1ALD8 C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628,
UniProt Related Accession:Q15063
Molecular Weight:80,357 Da
NCBI Full Name:Periostin
NCBI Synonym Full Names:periostin, osteoblast specific factor
NCBI Official Symbol:POSTN  
NCBI Official Synonym Symbols:PN; OSF2; OSF-2; PDLPOSTN; periostin  
NCBI Protein Information:periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like)
UniProt Protein Name:Periostin
UniProt Synonym Protein Names:Osteoblast-specific factor 2; OSF-2
Protein Family:Periostin
UniProt Gene Name:POSTN  
UniProt Entry Name:POSTN_HUMAN
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