Epigenetics & Nuclear Signaling Antibodies 3
Anti-PDPK1 Antibody (CAB1665)
- SKU:
- CAB1665
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Antibody Name: | Anti-PDPK1 Antibody |
Antibody SKU: | CAB1665 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-429 of human PDPK1 (NP_112558.2). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T, A-549, HCT116, Rat lung |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-429 of human PDPK1 (NP_112558.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | AGLP PFRA GNEY LIFQ KIIK LEYD FPEK FFPK ARDL VEKL LVLD ATKR LGCE EMEG YGPL KAHP FFES VTWE NLHQ QTPP KLTA YLPA MSED DEDC YGNY DNLL SQFG CMQV SSSS SSHS LSAS DTGL PQRS GSNI EQYI HDLD SNSF ELDL QFSE DEKR LLLE KQAG GNPW HQFV ENNL ILKM GPVD KRKG LFAR RRQL LLTE GPHL YYVD PVNK VLKG EIPW SQEL RPEA KNFK TFFV HTPN RTYY LMDP SGNA HKWC RKIQ EVWR QRYQ SHPD AAVQ |
Gene ID: | 5170 |
Uniprot: | O15530 |
Cellular Location: | Cell junction, Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, focal adhesion |
Calculated MW: | 48kDa/50kDa/58kDa/60kDa/63kDa |
Observed MW: | 58-68KDa |
Synonyms: | PDPK1, PDK1, PDPK2, PDPK2P, PRO0461 |
Background: | PDPK1 (3-phosphoinositide dependent protein kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and insulin receptor binding. |
UniProt Protein Function: | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca2+ entry and Ca2+-activated K+ channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. |
UniProt Code: | O15530 |
NCBI GenInfo Identifier: | 17380162 |
NCBI Gene ID: | 5170 |
NCBI Accession: | O15530.1 |
UniProt Secondary Accession: | O15530,Q59EH6, Q6FI20, Q8IV52, Q9BRD5, H0Y4Z0, |
UniProt Related Accession: | O15530,Q6A1A2 |
Molecular Weight: | 50,838 Da |
NCBI Full Name: | 3-phosphoinositide-dependent protein kinase 1 |
NCBI Synonym Full Names: | 3-phosphoinositide dependent protein kinase 1 |
NCBI Official Symbol: | PDPK1 |
NCBI Official Synonym Symbols: | PDK1; PDPK2; PDPK2P; PRO0461 |
NCBI Protein Information: | 3-phosphoinositide-dependent protein kinase 1 |
UniProt Protein Name: | 3-phosphoinositide-dependent protein kinase 1 |
Protein Family: | 3-phosphoinositide-dependent protein kinase |
UniProt Gene Name: | PDPK1 |
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