Cell Biology Antibodies 2

Anti-PDE7B Antibody (CAB12134)

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SKU:
CAB12134
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PDE7B Antibody
Antibody SKU:CAB12134
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 341-450 of human PDE7B (NP_061818.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 341-450 of human PDE7B (NP_061818.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VCEE FYRQ GELE QKFE LEIS PLCN QQKD SIPS IQIG FMSY IVEP LFRE WAHF TGNS TLSE NMLG HLAH NKAQ WKSL LPRQ HRSR GSSG SGPD HDHA GQGT ESEE QEGD SP
Gene ID:27115
Uniprot:Q9NP56
Cellular Location:
Calculated MW:51kDa
Observed MW:52kDa
Synonyms:PDE7B, bA472E5.1
Background:The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
UniProt Protein Function:PDE7B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
UniProt Protein Details:

Protein type:EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: cytosol

Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity

Biological Process: synaptic transmission

NCBI Summary:The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
UniProt Code:Q9NP56
NCBI GenInfo Identifier:13626185
NCBI Gene ID:27115
NCBI Accession:Q9NP56.1
UniProt Secondary Accession:Q9NP56,Q5W154,
UniProt Related Accession:Q9NP56
Molecular Weight:52kDa
NCBI Full Name:cAMP-specific 3',5'-cyclic phosphodiesterase 7B
NCBI Synonym Full Names:phosphodiesterase 7B
NCBI Official Symbol:PDE7B  
NCBI Official Synonym Symbols:bA472E5.1  
NCBI Protein Information:cAMP-specific 3',5'-cyclic phosphodiesterase 7B
UniProt Protein Name:cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Protein Family:cAMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name:PDE7B  
Anti-PDE7B Antibody (CAB12134)Western blot analysis of extracts of various cell lines, using PDE7B antibody (CAB12134) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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