Developmental Biology

Anti-PAX8 Antibody (CAB1009)

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SKU:
CAB1009
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-PAX8 Antibody
Antibody SKU:CAB1009
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PAX8 (NP_003457.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:SKOV3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PAX8 (NP_003457.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPHN SIRS GHGG LNQL GGAF VNGR PLPE VVRQ RIVD LAHQ GVRP CDIS RQLR VSHG CVSK ILGR YYET GSIR PGVI GGSK PKVA TPKV VEKI GDYK RQNP TMFA WEIR DRLL AEGV CDND TVPS VSSI NRII RTKV QQPF NLPM DSCV ATKS LSPG HTLI PSSA VTPP ESPQ SDSL GSTY SING LLGI AQPG SDKR KMDD SDQD SCRL SIDS
Gene ID:7849
Uniprot:Q06710
Cellular Location:Nucleus
Calculated MW:31kDa/34kDa/41kDa/43kDa/48kDa
Observed MW:51kDa
Synonyms:PAX8
Background:This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity

Biological Process: regulation of apoptosis; anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; mesonephros development; kidney development; pronephros development; urogenital system development

Disease: Hypothyroidism, Congenital, Nongoitrous, 2

NCBI Summary:This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
UniProt Code:Q06710
NCBI GenInfo Identifier:215273928
NCBI Gene ID:7849
NCBI Accession:Q06710.2
UniProt Related Accession:Q06710
Molecular Weight:48kDa
NCBI Full Name:Paired box protein Pax-8
NCBI Synonym Full Names:paired box 8
NCBI Official Symbol:PAX8  
NCBI Protein Information:paired box protein Pax-8
UniProt Protein Name:Paired box protein Pax-8
Protein Family:Paired box protein
UniProt Gene Name:PAX8  
UniProt Entry Name:PAX8_HUMAN
Anti-PAX8 Antibody (CAB1009)Western blot analysis of extracts of SKOV3 cells, using PAX8 antibody (CAB1009). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-PAX8 Antibody (CAB1009)Immunofluorescence analysis of U2OS cells using PAX8 antibody (CAB1009) at dilution of 1:100. Blue: DAPI for nuclear staining.
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