Epigenetics & Nuclear Signaling Antibodies 4

Anti-PARP3 Antibody (CAB7297)

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SKU:
CAB7297
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PARP3 Antibody
Antibody SKU:CAB7297
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-540 of human PARP3 (NP_001003931.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-540 of human PARP3 (NP_001003931.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LAQA LQAV SEQE KTVE EVPH PLDR DYQL LKCQ LQLL DSGA PEYK VIQT YLEQ TGSN HRCP TLQH IWKV NQEG EEDR FQAH SKLG NRKL LWHG TNMA VVAA ILTS GLRI MPHS GGRV GKGI YFAS ENSK SAGY VIGM KCGA HHVG YMFL GEVA LGRE HHIN TDNP SLKS PPPG FDSV IARG HTEP DPTQ DTEL ELDG QQVV VPQG QPVP CPEF SSST FSQS EYLI YQES QCRL RYLL EVHL
Gene ID:10039
Uniprot:Q9Y6F1
Cellular Location:Cytoplasm, Nucleus, centriole, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:60kDa
Observed MW:Refer to figures
Synonyms:PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
Background:The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:PARP3: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA repair, damage; EC 2.4.2.30; Transferase

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: centriole; nucleus

Molecular Function:catalytic activity; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; double-strand break repair; positive regulation of DNA ligation; DNA repair; telomere maintenance

NCBI Summary:The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y6F1
NCBI GenInfo Identifier:224471880
NCBI Gene ID:10039
NCBI Accession:Q9Y6F1.3
UniProt Secondary Accession:Q9Y6F1,Q8NER9, Q96CG2, Q9UG81,
UniProt Related Accession:Q9Y6F1
Molecular Weight:533
NCBI Full Name:Poly
NCBI Synonym Full Names:poly (ADP-ribose) polymerase family, member 3
NCBI Official Symbol:PARP3  
NCBI Official Synonym Symbols:IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3  
NCBI Protein Information:poly [ADP-ribose] polymerase 3; poly [ADP-ribose] polymerase 3; ADPRT-3; poly[ADP-ribose] synthase 3; NAD+ ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3; poly[ADP-ribose] synthetase 3; NAD(+) ADP-ribosyltransferase 3; ADP-ribosyltransferase diphtheria toxin-like 3; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
UniProt Protein Name:Poly [ADP-ribose] polymerase 3
UniProt Synonym Protein Names:ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3
Protein Family:Poly [ADP-ribose] polymerase
UniProt Gene Name:PARP3  
UniProt Entry Name:PARP3_HUMAN
Anti-PARP3 Antibody (CAB7297)Immunofluorescence analysis of MCF-7 cells using PARP3 antibody (CAB7297). Blue: DAPI for nuclear staining.
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