Anti-PARP2 Antibody (CAB5945)
- SKU:
- CAB5945
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ADPRT2
- Synonyms:
- ADPRTL2
- Synonyms:
- ADPRTL3
- Synonyms:
- ARTD2
- Synonyms:
- PARP-2
- Synonyms:
- pADPRT-2
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PARP2 Rabbit mAb |
| Product Code: | CAB5945 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PARP2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human PARP2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10038 |
| Uniprot: | Q9UGN5 |
| Calculated MW: | 66kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). |
| NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGN5 |
| NCBI GenInfo Identifier: | 110825961 |
| NCBI Gene ID: | 10038 |
| NCBI Accession: | NP_005475 |
| UniProt Secondary Accession: | Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8, |
| UniProt Related Accession: | Q9UGN5 |
| Molecular Weight: | 42.5 kDa (376aa) |
| NCBI Full Name: | poly |
| NCBI Synonym Full Names: | poly(ADP-ribose) polymerase 2 |
| NCBI Official Symbol: | PARP2 |
| NCBI Official Synonym Symbols: | ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2 |
| NCBI Protein Information: | poly [ADP-ribose] polymerase 2 |
| UniProt Protein Name: | Poly [ADP-ribose] polymerase 2 |
| UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2 |
| Protein Family: | Poly [ADP-ribose] polymerase |
| UniProt Gene Name: | PARP2 |
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