Anti-PAR4 Antibody (CAB4983)
- SKU:
- CAB4983
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PAR4
- Synonyms:
- Par-4
- Research Area:
- Cell Death
Description
| Product Name: | PAR4 Rabbit mAb |
| Product Code: | CAB4983 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PAR4, Par-4 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PAR4 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, SW620, 293T, Mouse lung |
| Immunogen: | A synthesized peptide derived from human PAR4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5074 |
| Uniprot: | Q96IZ0 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 40kDa |
| Observed MW: | 41kDa |
| UniProt Protein Function: | PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 12q21 Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus; actin cytoskeleton Molecular Function:protein binding; leucine zipper domain binding; enzyme binding; actin binding; transcription corepressor activity Biological Process: negative regulation of cell proliferation; actin filament bundle formation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of amyloid precursor protein biosynthetic process |
| NCBI Summary: | The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96IZ0 |
| NCBI GenInfo Identifier: | 66773935 |
| NCBI Gene ID: | 5074 |
| NCBI Accession: | Q96IZ0.1 |
| UniProt Secondary Accession: | Q96IZ0,O75796, Q6FHY9, Q8N700, |
| UniProt Related Accession: | Q96IZ0 |
| Molecular Weight: | 340 |
| NCBI Full Name: | PRKC apoptosis WT1 regulator protein |
| NCBI Synonym Full Names: | PRKC, apoptosis, WT1, regulator |
| NCBI Official Symbol: | PAWR |
| NCBI Official Synonym Symbols: | PAR4; Par-4 |
| NCBI Protein Information: | PRKC apoptosis WT1 regulator protein; WT1-interacting protein; prostate apoptosis response-4; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4 |
| UniProt Protein Name: | PRKC apoptosis WT1 regulator protein |
| UniProt Synonym Protein Names: | Prostate apoptosis response 4 protein; Par-4 |
| Protein Family: | PRKC apoptosis WT1 regulator protein |
| UniProt Gene Name: | PAWR |
| UniProt Entry Name: | PAWR_HUMAN |
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