Signal Transduction Antibodies 1

Anti-PANX2 Antibody (CAB12281)

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SKU:
CAB12281
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-PANX2 Antibody
Antibody SKU:CAB12281
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human PANX2 (NP_443071.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HepG2, Mouse brain, Rat kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human PANX2 (NP_443071.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FIFD KLHK VGIK TRRQ WRRS QFCD INIL AMFC NENR DHIK SLNR LDFI TNES DLMY DNVV RQLL AALA QSNH DATP TVRD SGVQ TVDP SANP AEPD GAAE PPVV KRPR KKMK WIPT SNPL PQPF KEPL AIMR VENS KAEK PKPA RRKT ATDT LIAP LLDR S
Gene ID:56666
Uniprot:Q96RD6
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, gap junction
Calculated MW:55kDa/70kDa/74kDa
Observed MW:65kDa
Synonyms:PANX2, PX2, hPANX2
Background:The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PANX2: Structural component of the gap junctions and the hemichannels. Belongs to the pannexin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: endomembrane system; plasma membrane

Molecular Function:gap junction hemi-channel activity; wide pore channel activity

Biological Process: cation transport; cell-cell signaling

NCBI Summary:The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Code:Q96RD6
NCBI GenInfo Identifier:296439257
NCBI Gene ID:56666
NCBI Accession:Q96RD6.2
UniProt Secondary Accession:Q96RD6,Q96RD5, Q9UGX8, B7Z684,
UniProt Related Accession:Q96RD6
Molecular Weight:74kDa
NCBI Full Name:Pannexin-2
NCBI Synonym Full Names:pannexin 2
NCBI Official Symbol:PANX2  
NCBI Official Synonym Symbols:PX2; hPANX2  
NCBI Protein Information:pannexin-2
UniProt Protein Name:Pannexin-2
Protein Family:Pannexin
UniProt Gene Name:PANX2  
Anti-PANX2 Antibody (CAB12281)Western blot analysis of extracts of various cell lines, using PANX2 antibody (CAB12281) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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