Epigenetics & Nuclear Signaling Antibodies 2

Anti-PABPN1 Antibody (CAB6041)

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SKU:
CAB6041
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Polyclonal AntibodyPN1 Rabbit Polyclonal Antibody
Antibody SKU:CAB6041
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (NP_004634.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:B cells, HeLa, HepG2, U-87MG, Mouse brain, Mouse testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (NP_004634.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAA AAAA AAAG AAGG RGSG PGRR RHLV PGAG GEAG EGAP GGAG DYGN GLES EELE PEEL LLEP EPEP EPEE EPPR PRAP PGAP GPGP GSGA PGSQ EEEE
Gene ID:8106
Uniprot:Q86U42
Cellular Location:Cytoplasm, Nucleus
Calculated MW:31kDa/32kDa/37kDa
Observed MW:45kDa
Synonyms:PABPN1, OPMD, PAB2, PABII, PABP-2, PABP2
Background:This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
UniProt Code:Q86U42
NCBI GenInfo Identifier:46403176
NCBI Gene ID:8106
NCBI Accession:Q86U42.3
UniProt Secondary Accession:Q86U42,O43484, D3DS49,
UniProt Related Accession:Q86U42
Molecular Weight:306
NCBI Full Name:Polyadenylate-binding protein 2
NCBI Synonym Full Names:poly(A) binding protein, nuclear 1
NCBI Official Symbol:PABPN1  
NCBI Official Synonym Symbols:OPMD; PAB2; PABII; PABP2; PABP-2  
NCBI Protein Information:polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein II
UniProt Protein Name:Polyadenylate-binding protein 2
UniProt Synonym Protein Names:Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; PABII; Polyadenylate-binding nuclear protein 1
UniProt Gene Name:PABPN1  
UniProt Entry Name:PABP2_HUMAN
Anti-PABPN1 Antibody (CAB6041)Western blot analysis of extracts of various cell lines, using PABPN1 antibody (CAB6041) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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