Epigenetics & Nuclear Signaling Antibodies 3

Anti-PA2G4 Antibody (CAB14037)

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SKU:
CAB14037
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-PA2G4 Antibody
Antibody SKU:CAB14037
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-394 of human PA2G4 (NP_006182.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, 22Rv1, K-562, BxPC-3, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-394 of human PA2G4 (NP_006182.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGE DEQQ EQTI AEDL VVTK YKMG GDIA NRVL RSLV EASS SGVS VLSL CEKG DAMI MEET GKIF KKEK EMKK GIAF PTSI SVNN CVCH FSPL KSDQ DYIL KEGD LVKI DLGV HVDG FIAN VAHT FVVD VAQG TQVT GRKA DVIK AAHL CAEA ALRL VKPG NQNT QVTE AWNK VAHS FNCT PIEG MLSH QLKQ HVID GEKT IIQN PTDQ QKKD HEKA EFEV HEVY AVDV LVSS GEGK AKDA GQRT TIYK RDPS KQYG LKMK TSRA FFSE VERR FDAM PFTL RAFE DEKK ARMG VVEC AKHE LLQP FNVL YEKE GEFV AQFK FTVL LMPN GPMR ITSG PFEP DLYK SEME VQDA ELKA LLQS SASR KTQK KKKK KASK TAEN ATSG ETLE ENEA GD
Gene ID:5036
Uniprot:Q9UQ80
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:38kDa/43kDa
Observed MW:40kDa
Synonyms:PA2G4, EBP1, HG4-1, p38-2G4
Background:This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
UniProt Protein Function:Ebp1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Belongs to the peptidase M24 family.
UniProt Protein Details:

Protein type:Nucleolus; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex

Molecular Function:protein binding; DNA binding; ubiquitin protein ligase binding; transcription factor activity

Biological Process: regulation of translation; cell proliferation; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; cell cycle arrest; rRNA processing; negative regulation of apoptosis

NCBI Summary:This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UQ80
NCBI GenInfo Identifier:13632817
NCBI Gene ID:5036
NCBI Accession:Q9UQ80.3
UniProt Secondary Accession:Q9UQ80,O43846, Q9UM59,
UniProt Related Accession:Q9UQ80
Molecular Weight:394
NCBI Full Name:Proliferation-associated protein 2G4
NCBI Synonym Full Names:proliferation-associated 2G4, 38kDa
NCBI Official Symbol:PA2G4  
NCBI Official Synonym Symbols:EBP1; HG4-1; p38-2G4  
NCBI Protein Information:proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog; proliferation-associated 2G4, 38kD
UniProt Protein Name:Proliferation-associated protein 2G4
UniProt Synonym Protein Names:Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1
Protein Family:Proliferation-associated protein
UniProt Gene Name:PA2G4  
UniProt Entry Name:PA2G4_HUMAN
Anti-PA2G4 Antibody (CAB14037)Western blot analysis of extracts of various cell lines, using PA2G4 antibody (CAB14037) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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