Cell Biology Antibodies 17

Anti-P2Y6 Antibody (CAB3708)

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SKU:
CAB3708
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-P2Y6 Antibody
Antibody SKU:CAB3708
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human P2Y6
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, U-937, U-87MG
Immunogen:A synthesized peptide derived from human P2Y6
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5031
Uniprot:Q15077
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:36kDa
Observed MW:42kDa
Synonyms:P2Y6
Background:The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
UniProt Protein Function:P2Y6: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function:G-protein coupled receptor activity; UDP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled

Biological Process: transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of smooth muscle cell migration

NCBI Summary:The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
UniProt Code:Q15077
NCBI GenInfo Identifier:2495018
NCBI Gene ID:5031
NCBI Accession:Q15077.1
UniProt Related Accession:Q15077
Molecular Weight:36kDa
NCBI Full Name:P2Y purinoceptor 6
NCBI Synonym Full Names:pyrimidinergic receptor P2Y6
NCBI Official Symbol:P2RY6  
NCBI Official Synonym Symbols:P2Y6  
NCBI Protein Information:P2Y purinoceptor 6
UniProt Protein Name:P2Y purinoceptor 6
UniProt Gene Name:P2RY6  
UniProt Entry Name:P2RY6_HUMAN
Anti-P2Y6 Antibody (CAB3708)Western blot - P2Y6 Rabbit mAb (CAB3708)
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