Cardiovascular Antibodies
Anti-P2RY12 Antibody (CAB1710)
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- SKU:
- CAB1710
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-P2RY12 Antibody |
| Antibody SKU: | CAB1710 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human P2RY12 (NP_795345.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, HepG2, PC-12, DU145, Mouse brain, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human P2RY12 (NP_795345.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | INFL IVIV CYTL ITKE LYRS YVRT RGVG KVPR KKVN VKVF IIIA VFFI CFVP FHFA RIPY TLSQ TRDV FDCT AENT LFYV KEST LWLT SLNA CLDP FIYF FLCK SFRN SLIS MLKC PNSA TSLS QDNR KKEQ DGGD PNEE TPM |
| Gene ID: | 64805 |
| Uniprot: | Q9H244 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 50kDa |
| Synonyms: | P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999 |
| Background: | The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. |
| UniProt Code: | Q9H244 |
| NCBI GenInfo Identifier: | 12232483 |
| NCBI Gene ID: | 64805 |
| NCBI Accession: | NP_073625 |
| UniProt Secondary Accession: | Q9H244,Q546J7, D3DNJ5, |
| UniProt Related Accession: | Q9H244 |
| Molecular Weight: | 39,439 Da |
| NCBI Full Name: | P2Y purinoceptor 12 |
| NCBI Synonym Full Names: | purinergic receptor P2Y, G-protein coupled, 12 |
| NCBI Official Symbol: | P2RY12 |
| NCBI Official Synonym Symbols: | HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc) |
| NCBI Protein Information: | P2Y purinoceptor 12; ADP-glucose receptor; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2Y12 platelet ADP receptor; purinergic receptor P2RY12; putative G-protein coupled receptor |
| UniProt Protein Name: | P2Y purinoceptor 12 |
| UniProt Synonym Protein Names: | ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999 |
| Protein Family: | Proteinase-activated receptor |
| UniProt Gene Name: | P2RY12 |
| UniProt Entry Name: | P2Y12_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RY12 antibody (CAB1710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of C6 cells using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-87MG cells using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse brain using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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