Cardiovascular Antibodies
Anti-P2RY1 Antibody (CAB7706)
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- SKU:
- CAB7706
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-P2RY1 Antibody |
| Antibody SKU: | CAB7706 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 274-373 of human P2RY1 (NP_002554.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, Rat liver, Rat intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 274-373 of human P2RY1 (NP_002554.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IPFH VMKT MNLR ARLD FQTP AMCA FNDR VYAT YQVT RGLA SLNS CVDP ILYF LAGD TFRR RLSR ATRK ASRR SEAN LQSK SEDM TLNI LPEF KQNG DTSL |
| Gene ID: | 5028 |
| Uniprot: | P47900 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | P2RY1, P2Y1 |
| Background: | The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. |
| UniProt Protein Function: | P2RY1: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q25.2 Cellular Component: cell surface; dendrite; integral to plasma membrane; plasma membrane; postsynaptic membrane Molecular Function:ATP-activated nucleotide receptor activity; protein binding; purinergic nucleotide receptor activity, G-protein coupled; receptor activity Biological Process: cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; positive regulation of protein amino acid phosphorylation |
| NCBI Summary: | The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47900 |
| NCBI GenInfo Identifier: | 1352692 |
| NCBI Gene ID: | 5028 |
| NCBI Accession: | P47900.1 |
| UniProt Related Accession: | P47900 |
| Molecular Weight: | 42,072 Da |
| NCBI Full Name: | P2Y purinoceptor 1 |
| NCBI Synonym Full Names: | purinergic receptor P2Y1 |
| NCBI Official Symbol: | P2RY1 |
| NCBI Official Synonym Symbols: | P2Y1 |
| NCBI Protein Information: | P2Y purinoceptor 1 |
| UniProt Protein Name: | P2Y purinoceptor 1 |
| UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
| Protein Family: | P2Y purinoceptor |
| UniProt Gene Name: | P2RY1 |
| UniProt Entry Name: | P2RY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RY1 antibody (CAB7706) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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