Name: Anti-OSMR Antibody (CAB6681)
Brand: Cell Biology Antibodies 10
SKU: CAB6681
Availability: OutOfStock

Antibody Name:	Anti-OSMR Antibody
Antibody SKU:	CAB6681
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human OSMR (NP_003990.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	293T, Raji

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human OSMR (NP_003990.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LPLT PVSL KVST NSTR QSLH LQWT VHNL PYHQ ELKM VFQI QISR IETS NVIW VGNY STTV KWNQ VLHW SWES ELPL ECAT HFVR IKSL VDDA KFPE PNFW SNWS SWEE VSVQ DSTG QDIL FVFP KDKL VEEG TNVT ICYV SRNI QNNV SCYL EGKQ IHGE QLDP HVTA FNLN SVPF IRNK GTNI YCEA SQGN VSEG MKGI VLFV SKVL EEPK DFSC ETED FKTL HCTW DPGT DTAL GWSK QPSQ SYTL FESF SGEK KLCT HKNW CNWQ ITQD SQET YNFT LIAE NYLR KRSV NILF NLTH R
Gene ID:	9180
Uniprot:	Q99650
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	39kDa/110kDa
Observed MW:	111KDa

Synonyms:

OSMR, IL-31R-beta, IL-31RB, OSMRB, PLCA1

Background:

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: oncostatin-M receptor complex Molecular Function:oncostatin-M receptor activity; growth factor binding Biological Process: positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation Disease: Amyloidosis, Primary Localized Cutaneous, 1
NCBI Summary:	This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Code:	Q99650
NCBI GenInfo Identifier:	74724833
NCBI Gene ID:	9180
NCBI Accession:	Q99650.1
UniProt Secondary Accession:	Q99650,Q6P4E8, Q96QJ6,
UniProt Related Accession:	Q99650
Molecular Weight:	Calculated MW: 39kDa/110kDaObserved MW: 111kDa
NCBI Full Name:	Oncostatin-M-specific receptor subunit beta
NCBI Synonym Full Names:	oncostatin M receptor
NCBI Official Symbol:	OSMR
NCBI Official Synonym Symbols:	OSMRB; PLCA1
NCBI Protein Information:	oncostatin-M-specific receptor subunit beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit
UniProt Protein Name:	Oncostatin-M-specific receptor subunit beta
UniProt Synonym Protein Names:	Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
Protein Family:	Oncostatin-M-specific receptor
UniProt Gene Name:	OSMR
UniProt Entry Name:	OSMR_HUMAN

Western blot analysis of extracts of various cell lines, using OSMR Rabbit pAb (CAB6681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

ELISA Kits

Human OSMR(Oncostatin M Receptor) ELISA Kit

Human OSMR (Oncostatin M Receptor) CLIA Kit (HUES01192)

Human Oncostatin-M-specific receptor subunit beta (OSMR) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)