Epigenetics & Nuclear Signaling Antibodies 4

Anti-NUP155 Antibody (CAB7764)

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SKU:
CAB7764
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NUP155 Antibody
Antibody SKU:CAB7764
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1102-1391 of human NUP155 (NP_705618.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, HeLa, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1102-1391 of human NUP155 (NP_705618.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ADMH STEI SLQQ RLEY IARA ILSA KSST AISS IAAD GEFL HELE EKME VARI QLQI QETL QRQY SHHS SVQD AVSQ LDSE LMDI TKLY GEFA DPFK LAEC KLAI IHCA GYSD PILV QTLW QDII EKEL SDSV TLSS SDRM HALS LKIV LLGK IYAG TPRF FPLD FIVQ FLEQ QVCT LNWD VGFV IQTM NEIG VPLP RLLE VYDQ LFKS RDPF WNRM KKPL HLLD CIHV LLIR YVEN PSQV LNCE RRRF TNLC LDAV CGYL VELQ SMSS SVAV QAIT GNFK SLQA KLER LH
Gene ID:9631
Uniprot:O75694
Cellular Location:Cytoplasmic side, Nucleoplasmic side, Nucleus, Nucleus membrane, Peripheral membrane protein, nuclear pore complex
Calculated MW:149kDa/155kDa
Observed MW:155kDa
Synonyms:NUP155, ATFB15, N155
Background:Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6.
UniProt Protein Function:NUP155: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleoporin

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: membrane; nuclear envelope

Molecular Function:protein binding; structural constituent of nuclear pore; transporter activity

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; nuclear membrane organization and biogenesis; protein import into nucleus; protein sumoylation; RNA export from nucleus; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription

Disease: Atrial Fibrillation, Familial, 15

NCBI Summary:Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
UniProt Code:O75694
NCBI GenInfo Identifier:6093462
NCBI Gene ID:9631
NCBI Accession:O75694.1
UniProt Secondary Accession:O75694,Q9UBE9, Q9UFL5,
UniProt Related Accession:O75694
Molecular Weight:149,016 Da
NCBI Full Name:Nuclear pore complex protein Nup155
NCBI Synonym Full Names:nucleoporin 155
NCBI Official Symbol:NUP155  
NCBI Official Synonym Symbols:N155; ATFB15  
NCBI Protein Information:nuclear pore complex protein Nup155
UniProt Protein Name:Nuclear pore complex protein Nup155
UniProt Synonym Protein Names:155 kDa nucleoporin; Nucleoporin Nup155
Protein Family:Nuclear pore complex protein
UniProt Gene Name:NUP155  
UniProt Entry Name:NU155_HUMAN
Anti-NUP155 Antibody (CAB7764)Western blot analysis of extracts of various cell lines, using NUP155 Antibody (CAB7764) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s.
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