| UniProt Protein Function: | TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Trk family Chromosomal Location of Human Ortholog: 15q25 Cellular Component: integral to plasma membrane; cytoplasm; receptor complex Molecular Function:neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; activation of protein kinase B; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; response to corticosterone stimulus |
| NCBI Summary: | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q16288 |
| NCBI GenInfo Identifier: | 59889562 |
| NCBI Gene ID: | 4916 |
| NCBI Accession: | NP_001012338.1 |
| UniProt Secondary Accession: | Q16288,O75682, Q12827, Q16289, |
| UniProt Related Accession: | Q16288 |
| Molecular Weight: | 94,428 Da |
| NCBI Full Name: | NT-3 growth factor receptor isoform a |
| NCBI Synonym Full Names: | neurotrophic tyrosine kinase, receptor, type 3 |
| NCBI Official Symbol: | NTRK3 |
| NCBI Official Synonym Symbols: | TRKC; gp145(trkC) |
| NCBI Protein Information: | NT-3 growth factor receptor; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein |
| UniProt Protein Name: | NT-3 growth factor receptor |
| UniProt Synonym Protein Names: | GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase |
| UniProt Gene Name: | NTRK3 |
| UniProt Entry Name: | NTRK3_HUMAN |
