Cell Biology Antibodies 8

Anti-NRG4 Antibody (CAB2599)

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SKU:
CAB2599
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NRG4 Antibody
Antibody SKU:CAB2599
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human NRG4 (NP_612640.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HepG2, BxPC-3, Rat thymus, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human NRG4 (NP_612640.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPTD HEEP CGPS HKSF CLNG GLCY VIPT IPSP FCRC VENY TGAR CEEV FLPG SSIQ TKSN LFEA FVAL AVLV TLII GAFY FLCR KGHF QRAS SVQY DINL VETS STSA HHSH EQH
Gene ID:145957
Uniprot:Q8WWG1
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:12kDa
Observed MW:15kDa
Synonyms:NRG4, HRG4
Background:
UniProt Protein Function:NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane

Molecular Function:growth factor activity; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response

NCBI Summary:The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8WWG1
NCBI GenInfo Identifier:28201832
NCBI Gene ID:145957
NCBI Accession:Q8WWG1.1
UniProt Secondary Accession:Q8WWG1,A6NIE8,
UniProt Related Accession:Q8WWG1
Molecular Weight:
NCBI Full Name:Pro-neuregulin-4, membrane-bound isoform
NCBI Synonym Full Names:neuregulin 4
NCBI Official Symbol:NRG4  
NCBI Official Synonym Symbols:HRG4  
NCBI Protein Information:pro-neuregulin-4, membrane-bound isoform; pro-NRG4; heregulin 4
UniProt Protein Name:Pro-neuregulin-4, membrane-bound isoform
Protein Family:Pro-neuregulin
UniProt Gene Name:NRG4  
UniProt Entry Name:NRG4_HUMAN
Anti-NRG4 Antibody (CAB2599)Western blot analysis of extracts of various cell lines, using NRG4 antibody (CAB2599) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.
Anti-NRG4 Antibody (CAB2599)Immunohistochemistry of paraffin-embedded rat brain using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens).
Anti-NRG4 Antibody (CAB2599)Immunohistochemistry of paraffin-embedded human stomach using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens).
Anti-NRG4 Antibody (CAB2599)Immunohistochemistry of paraffin-embedded mouse lung using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens).
Anti-NRG4 Antibody (CAB2599)Immunohistochemistry of paraffin-embedded mouse brain using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens).
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