KO Validated Antibodies 2

Anti-NRD1 Antibody (CAB19857)[KO Validated]

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SKU:
CAB19857
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NRD1 Antibody [KO Validated]
Antibody SKU:CAB19857
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human NRD1.
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human NRD1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4898
Uniprot:O43847
Cellular Location:
Calculated MW:131kDa/139kDa
Observed MW:131KDa
Anti-NRD1 Antibody [KO Validated] (CAB19857)Western blot analysis of extracts from normal (control) and NRD1 knockout (KO) 293T cells, using NRD1 antibody (CAB19857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:NRDC, NRD1, hNRD1, hNRD2
Background:This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:NRD1: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.24.61

Chromosomal Location of Human Ortholog: 1p32.2-p32.1

Cellular Component: cell surface; cytosol

Molecular Function:epidermal growth factor binding; metalloendopeptidase activity; protein binding; zinc ion binding

Biological Process: cell migration; cell proliferation; neuromuscular junction development; positive regulation of membrane protein ectodomain proteolysis; protein processing; regulation of endopeptidase activity

NCBI Summary:This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
UniProt Code:O43847
NCBI GenInfo Identifier:29840826
NCBI Gene ID:4898
NCBI Accession:O43847.2
UniProt Secondary Accession:O43847,O15241, O15242, Q5VUL0, Q96HB2, Q9NU57, A6NI41
UniProt Related Accession:O43847
Molecular Weight:139,284 Da
NCBI Full Name:Nardilysin
NCBI Synonym Full Names:nardilysin convertase
NCBI Official Symbol:NRDC  
NCBI Official Synonym Symbols:NRD1; hNRD1; hNRD2  
NCBI Protein Information:nardilysin
UniProt Protein Name:Nardilysin
UniProt Synonym Protein Names:N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase
Protein Family:Negative regulator of differentiation
UniProt Gene Name:NRDC  
UniProt Entry Name:NRDC_HUMAN
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