Epigenetics & Nuclear Signaling Antibodies 3
Anti-NR5A1 Antibody (CAB1657)
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- SKU:
- CAB1657
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NR5A1 Antibody |
| Antibody SKU: | CAB1657 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human NR5A1 (NP_004950.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis, Rat ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human NR5A1 (NP_004950.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDYS YDED LDEL CPVC GDKV SGYH YGLL TCES CKGF FKRT VQNN KHYT CTES QSCK IDKT QRKR CPFC RFQK CLTV GMRL EAVR ADRM RGGR NKFG PMYK RDRA LKQQ KKAQ IRAN GFKL |
| Gene ID: | 2516 |
| Uniprot: | Q13285 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa |
| Observed MW: | 52kDa |
| Synonyms: | NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, SRXX4 |
| Background: | The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. |
| UniProt Protein Function: | STF-1: a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. |
| UniProt Protein Details: | Protein type:Nuclear receptor Chromosomal Location of Human Ortholog: 9q33 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity Biological Process: cell-cell signaling; hormone-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; primary sex determination; regulation of steroid biosynthetic process; tissue development; transcription initiation from RNA polymerase II promoter Disease: 46,xy Sex Reversal 3; Premature Ovarian Failure 7; Spermatogenic Failure 8 |
| NCBI Summary: | The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13285 |
| NCBI GenInfo Identifier: | 3121738 |
| NCBI Gene ID: | 2516 |
| NCBI Accession: | Q13285.2 |
| UniProt Secondary Accession: | Q13285,O15196, Q5T6F5, |
| UniProt Related Accession: | Q13285 |
| Molecular Weight: | 51,636 Da |
| NCBI Full Name: | Steroidogenic factor 1 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 5 group A member 1 |
| NCBI Official Symbol: | NR5A1 |
| NCBI Official Synonym Symbols: | ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; hSF-1 |
| NCBI Protein Information: | steroidogenic factor 1 |
| UniProt Protein Name: | Steroidogenic factor 1 |
| UniProt Synonym Protein Names: | Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP |
| Protein Family: | Steroidogenic factor |
| UniProt Gene Name: | NR5A1 |
| UniProt Entry Name: | STF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NR5A1 antibody (CAB1657) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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