Cell Biology Antibodies 6

Anti-NPPA Antibody (CAB1609)

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SKU:
CAB1609
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPPA Antibody
Antibody SKU:CAB1609
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-151 of human NPPA (NP_006163.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:mouse brain, mouse heart, mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-151 of human NPPA (NP_006163.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NPMY NAVS NADL MDFK NLLD HLEE KMPL EDEV VPPQ VLSE PNEE AGAA LSPL PEVP PWTG EVSP AQRD GGAL GRGP WDSS DRSA LLKS KLRA LLTA PRSL RRSS CFGG RMDR IGAQ SGLG CNSF RY
Gene ID:4878
Uniprot:P01160
Cellular Location:Secreted
Calculated MW:16kDa
Observed MW:16kDa
Synonyms:NPPA, ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND, NPPA
Background:The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1.
UniProt Protein Function:NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.
UniProt Protein Details:

Protein type:Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus

Molecular Function:neuropeptide hormone activity; peptide hormone receptor binding; receptor binding

Biological Process: cardiac muscle hypertrophy; transcription initiation from RNA polymerase II promoter; cGMP biosynthetic process; negative regulation of systemic arterial blood pressure; positive regulation of heart rate; female pregnancy; response to insulin stimulus; neuropeptide signaling pathway; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; response to hypoxia; gene expression; negative regulation of cell growth; regulation of blood vessel size

Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6

NCBI Summary:The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
UniProt Code:P01160
NCBI GenInfo Identifier:113864
NCBI Gene ID:4878
NCBI Accession:P01160.1
UniProt Secondary Accession:P01160,Q13766, Q5JZE1,
UniProt Related Accession:P01160
Molecular Weight:153
NCBI Full Name:Natriuretic peptides A
NCBI Synonym Full Names:natriuretic peptide A
NCBI Official Symbol:NPPA  
NCBI Official Synonym Symbols:ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF  
NCBI Protein Information:natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A
UniProt Protein Name:Natriuretic peptides A
UniProt Synonym Protein Names:CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDP; Atrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP
UniProt Gene Name:NPPA  
UniProt Entry Name:ANF_HUMAN
Anti-NPPA Antibody (CAB1609)Western blot analysis of extracts of various cell lines, using NPPA antibody (CAB1609) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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