Cell Biology Antibodies 6
Anti-NPPA Antibody (CAB1609)
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- SKU:
- CAB1609
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NPPA Antibody |
| Antibody SKU: | CAB1609 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-151 of human NPPA (NP_006163.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | mouse brain, mouse heart, mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-151 of human NPPA (NP_006163.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NPMY NAVS NADL MDFK NLLD HLEE KMPL EDEV VPPQ VLSE PNEE AGAA LSPL PEVP PWTG EVSP AQRD GGAL GRGP WDSS DRSA LLKS KLRA LLTA PRSL RRSS CFGG RMDR IGAQ SGLG CNSF RY |
| Gene ID: | 4878 |
| Uniprot: | P01160 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | NPPA, ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND, NPPA |
| Background: | The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. |
| UniProt Protein Function: | NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family. |
| UniProt Protein Details: | Protein type:Hormone; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36.21 Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus Molecular Function:neuropeptide hormone activity; peptide hormone receptor binding; receptor binding Biological Process: cardiac muscle hypertrophy; transcription initiation from RNA polymerase II promoter; cGMP biosynthetic process; negative regulation of systemic arterial blood pressure; positive regulation of heart rate; female pregnancy; response to insulin stimulus; neuropeptide signaling pathway; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; response to hypoxia; gene expression; negative regulation of cell growth; regulation of blood vessel size Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6 |
| NCBI Summary: | The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P01160 |
| NCBI GenInfo Identifier: | 113864 |
| NCBI Gene ID: | 4878 |
| NCBI Accession: | P01160.1 |
| UniProt Secondary Accession: | P01160,Q13766, Q5JZE1, |
| UniProt Related Accession: | P01160 |
| Molecular Weight: | 153 |
| NCBI Full Name: | Natriuretic peptides A |
| NCBI Synonym Full Names: | natriuretic peptide A |
| NCBI Official Symbol: | NPPA |
| NCBI Official Synonym Symbols: | ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF |
| NCBI Protein Information: | natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A |
| UniProt Protein Name: | Natriuretic peptides A |
| UniProt Synonym Protein Names: | CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDP; Atrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP |
| UniProt Gene Name: | NPPA |
| UniProt Entry Name: | ANF_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NPPA antibody (CAB1609) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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