Metabolism Antibodies 3
Anti-NME2 Antibody (CAB5621)
- SKU:
- CAB5621
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-NME2 Antibody |
| Antibody SKU: | CAB5621 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NME2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Mouse heart, Rat brain, Rat kidney, Rat heart |
| Immunogen: | A synthesized peptide derived from human NME2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4831 |
| Uniprot: | P22392 |
| Cellular Location: | |
| Calculated MW: | 17kDa |
| Observed MW: | 17KDa |
| Synonyms: | NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF |
| Background: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
| UniProt Protein Function: | NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.13.3; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Kinase, other; EC 2.7.4.6; Other group; NDK family Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle Molecular Function:nucleoside diphosphate kinase activity; protein binding; transcription factor activity Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent |
| NCBI Summary: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P22392 |
| NCBI GenInfo Identifier: | 127983 |
| NCBI Gene ID: | 4831 |
| NCBI Accession: | P22392.1 |
| UniProt Secondary Accession: | P22392,Q1WM23, Q6LCT6, A8MWA3, |
| UniProt Related Accession: | P22392 |
| Molecular Weight: | 30,137 Da |
| NCBI Full Name: | Nucleoside diphosphate kinase B |
| NCBI Synonym Full Names: | NME/NM23 nucleoside diphosphate kinase 2 |
| NCBI Official Symbol: | NME2 |
| NCBI Official Synonym Symbols: | PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2 |
| NCBI Protein Information: | nucleoside diphosphate kinase B |
| UniProt Protein Name: | Nucleoside diphosphate kinase B |
| UniProt Synonym Protein Names: | C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2 |
| UniProt Gene Name: | NME2 |
| UniProt Entry Name: | NDKB_HUMAN |
 | Western blot - NME2 Rabbit mAb (CAB5621) |
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