Description
| Product Name: | NKX3.1 Rabbit mAb |
| Product Code: | CAB19734 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BAPX2, NKX3, NKX3.1, NKX3A |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NKX3.1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, DU145, PC-3 |
| Immunogen: | A synthesized peptide derived from human NKX3.1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4824 |
| Uniprot: | Q99801 |
| Calculated MW: | 32kDa |
| Observed MW: | 35KDa |
| UniProt Protein Function: | NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: intracellular; nucleusMolecular Function: androgen receptor activity; caspase activator activity; estrogen receptor activity; estrogen receptor binding; histone deacetylase binding; protein binding; protein kinase activator activity; protein self-association; sequence-specific DNA binding; transcription factor activity; transcription factor bindingBiological Process: androgen receptor signaling pathway; branching morphogenesis of a tube; caspase activation; multicellular organismal development; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein kinase B signaling cascade; response to testosterone stimulus; salivary gland development |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q99801 |
| NCBI GenInfo Identifier: | 17377578 |
| NCBI Gene ID: | 4824 |
| NCBI Accession: | Q99801.2 |
| UniProt Secondary Accession: | Q99801,O15465, Q9H2P4, Q9H2P5, Q9H2P6, Q9H2P7, Q9HBG0 |
| UniProt Related Accession: | Q99801 |
| Molecular Weight: | 21,626 Da |
| NCBI Full Name: | Homeobox protein Nkx-3.1 |
| NCBI Synonym Full Names: | NK3 homeobox 1 |
| NCBI Official Symbol: | NKX3-1 |
| NCBI Official Synonym Symbols: | NKX3; BAPX2; NKX3A; NKX3.1 |
| NCBI Protein Information: | homeobox protein Nkx-3.1 |
| UniProt Protein Name: | Homeobox protein Nkx-3.1 |
| UniProt Synonym Protein Names: | Homeobox protein NK-3 homolog A |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | NKX3-1 |
| UniProt Entry Name: | NKX31_HUMAN |
