Epigenetics & Nuclear Signaling Antibodies 3

Anti-NKRF Antibody (CAB4853)

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SKU:
CAB4853
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NKRF
Synonyms:
ITBA4
Synonyms:
NRF
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:NKRF Rabbit pAb
Product Code:CAB4853
Size:20uL, 50uL, 100uL
Synonyms:NKRF, ITBA4, NRF
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human NKRF (NP_060014.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-549, Mouse brain, Mouse spleen, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human NKRF (NP_060014.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YGTK KTSK HAAA DEAL KILQ KTQP TYPS VKSS QCHT GSSP RGSG KKKD IKDL VVYE NSSN PVCT LNDT AQFN RMTV EYVY ERMT GLRW KCKV ILES EVIA EAVG VKKT VKYE AAGE AVKT LKKT QPTV INNL KKGA VEDV ISRN EIQG RSAE EAYK QQIK EDNI GNQL LRKM GWTG GGLG KSGE GIRE PISV KEQH KREG LGLD VERV NKIA KRDI EQII RNYA RSES HTDL TFSR ELTN DERK QIHQ IAQK YGLK SKSH GVGH DRYL VVGR KRRK EDLL DQLK QEGQ VGHY ELVM PQAN
Gene ID:55922
Uniprot:O15226
Cellular Location:Nucleus, nucleolus
Calculated MW:77kDa/79kDa
Observed MW:78KDa
UniProt Protein Function:NKRF: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
UniProt Protein Details:

Protein type:Nucleolus; RNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: endoplasmic reticulum; nucleolus; nucleus

Molecular Function:protein binding; DNA binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Code:O15226
NCBI GenInfo Identifier:33860178
NCBI Gene ID:55922
NCBI Accession:O15226.2
UniProt Secondary Accession:O15226,Q4VC41, Q9UJ91, G3V1N1,
UniProt Related Accession:O15226
Molecular Weight:690
NCBI Full Name:NF-kappa-B-repressing factor
NCBI Synonym Full Names:NFKB repressing factor
NCBI Official Symbol:NKRF  
NCBI Official Synonym Symbols:NRF; ITBA4  
NCBI Protein Information:NF-kappa-B-repressing factor; transcription factor NRF
UniProt Protein Name:NF-kappa-B-repressing factor
UniProt Synonym Protein Names:Protein ITBA4; Transcription factor NRF
Protein Family:NF-kappa-B-repressing factor
UniProt Gene Name:NKRF  
UniProt Entry Name:NKRF_HUMAN
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