Cell Biology Antibodies 1
Anti-NFKBIL-1 Antibody (CAB10456)
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- SKU:
- CAB10456
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | NFKBIL1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB10456 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human NFKBIL1 (NP_004998.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, HL-60, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human NFKBIL1 (NP_004998.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSNP SPQV PEEE ASTS VCRP KSSM ASTS RRQR RERR FRRY LSAG RLVR AQAL LQRH PGLD VDAG QPPP LHRA CARH DAPA LCLL LRLG ADPA HQDR HGDT ALHA AARQ GPDA YTDF FLPL LSRC PSAM GIKN KDGE TPGQ ILGW GPPW DSAE EEEE DDAS KERE WRQK LQGE LEDE WQEV MGRF EGDA SHET QEPE SFSA WSDR LARE HAQK CQQQ QREA EGSR RPPR AEGS SQSW RQQE EEQR LFRE RARA KEEE LRES RARR AQEA LGDR EPKP TRAG PREE HPRG AGRG SLWR FGDV PWPC PGGG DPEA MAAA LVAR GPPL EEQG ALRR YLRV QQVR WHPD RFLQ RFRS QIET WELG RVMG AVTA LSQA LNRH AEAL K |
| Gene ID: | 4795 |
| Uniprot: | Q9UBC1 |
| Cellular Location: | Nucleus |
| Calculated MW: | 40kDa/41kDa/43kDa |
| Observed MW: | 43kDa |
| Synonyms: | NFKBIL1, IKBL, LST1, NFKBIL |
| Background: | This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NFKBIL1: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 6p21.33 Cellular Component: intermediate filament cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production Disease: Rheumatoid Arthritis |
| NCBI Summary: | This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9UBC1 |
| NCBI GenInfo Identifier: | 44888077 |
| NCBI Gene ID: | 4795 |
| NCBI Accession: | Q9UBC1.1 |
| UniProt Secondary Accession: | Q9UBC1,Q14625, Q5HYU4, Q5RJ72, Q5ST96, Q5STV4, Q5STV5 Q9UBX4, A6NL91, B4DUW1, |
| UniProt Related Accession: | Q9UBC1 |
| Molecular Weight: | 41,368 Da |
| NCBI Full Name: | NF-kappa-B inhibitor-like protein 1 |
| NCBI Synonym Full Names: | NFKB inhibitor like 1 |
| NCBI Official Symbol: | NFKBIL1 |
| NCBI Official Synonym Symbols: | IKBL; LST1; NFKBIL |
| NCBI Protein Information: | NF-kappa-B inhibitor-like protein 1 |
| UniProt Protein Name: | NF-kappa-B inhibitor-like protein 1 |
| UniProt Synonym Protein Names: | Inhibitor of kappa B-like protein; I-kappa-B-like protein; IkappaBL; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
| Protein Family: | NF-kappa-B inhibitor-like protein |
| UniProt Gene Name: | NFKBIL1 |
 | Western blot analysis of extracts of various cell lines, using NFKBIL1 antibody (CAB10456) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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