Cell Biology Antibodies 13

Anti-NFATC4 Antibody (CAB17511)

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SKU:
CAB17511
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NFATC4 Antibody
Antibody SKU:CAB17511
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 560-710 of human NFATC4 (NP_004545.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SKOV3, HepG2, A-549, Mouse lung, Mouse kidney, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 560-710 of human NFATC4 (NP_004545.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QGGG KVVS VQAA SVPI ECSQ RSAQ ELPQ VEAY SPSA CSVR GGEE LVLT GSNF LPDS KVVF IERG PDGK LQWE EEAT VNRL QSNE VTLT LTVP EYSN KRVS RPVQ VYFY VSNG RRKR SPTQ SFRF LPVI CKEE PLPD SSLR GFPS ASAT PFG
Gene ID:4776
Uniprot:Q14934
Cellular Location:
Calculated MW:
Observed MW:108kDa
Anti-NFATC4 Antibody (CAB17511)Western blot - NFATC4 Polyclonal Antibody (CAB17511)
Synonyms:NF-AT3, NF-ATC4, NFAT3, NFATC4
Background:This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Protein Function:NFAT3: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. 23 alternatively spliced isoforms of the human protein hve been reported.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus; transcription factor complex

Molecular Function:peroxisome proliferator activated receptor binding; protein binding; transcription coactivator activity; transcription factor binding

Biological Process: calcineurin-NFAT signaling pathway; cellular respiration; DNA damage response, signal transduction resulting in induction of apoptosis; heart development; inflammatory response; muscle cell development; negative regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of synaptic plasticity; smooth muscle cell differentiation; transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Code:Q14934
NCBI GenInfo Identifier:215274090
NCBI Gene ID:4776
NCBI Accession:Q14934.2
UniProt Secondary Accession:Q14934,B4DDG5, B4DY55, B5B2U7, B5B2U8, B5B2U9, B5B2V0 B5B2V1, B5B2V2, B5B2V3, B5B2V4, B5B2V5,
UniProt Related Accession:Q14934
Molecular Weight:8,950 Da
NCBI Full Name:Nuclear factor of activated T-cells, cytoplasmic 4
NCBI Synonym Full Names:nuclear factor of activated T-cells 4
NCBI Official Symbol:NFATC4  
NCBI Official Synonym Symbols:NFAT3; NF-AT3; NF-ATC4  
NCBI Protein Information:nuclear factor of activated T-cells, cytoplasmic 4
UniProt Protein Name:Nuclear factor of activated T-cells, cytoplasmic 4
UniProt Synonym Protein Names:T-cell transcription factor NFAT3; NF-AT3
Protein Family:Nuclear factor of activated T-cells
UniProt Gene Name:NFATC4  
UniProt Entry Name:NFAC4_HUMAN
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