Immunology Antibodies 3

Anti-NFAM1 Antibody (CAB15570)

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SKU:
CAB15570
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-NFAM1 Antibody
Antibody SKU:CAB15570
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 186-270 of human NFAM1 (NP_666017.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 186-270 of human NFAM1 (NP_666017.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WNKK RMRG PGKD PTRK CPDP RSAS SPKQ HPSE SVYT ALQR RETE VYAC IENE DGSS PTAK QSPL SQER PHRF EDDG ELNL VYEN L
Gene ID:150372
Uniprot:Q8NET5
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:29kDa
Observed MW:30kDa
Synonyms:NFAM1, CNAIP
Background:The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells.
UniProt Protein Function:NFAM1: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cell surface; integral to membrane; intracellular; lipid raft; plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: B cell differentiation; B cell receptor signaling pathway; inflammatory response; positive regulation of B cell receptor signaling pathway; positive regulation of cytokine production; positive regulation of transcription factor activity; regulation of B cell differentiation; signal transduction

NCBI Summary:The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NET5
NCBI GenInfo Identifier:22095335
NCBI Gene ID:150372
NCBI Accession:NP_666017.1
UniProt Secondary Accession:Q8NET5,Q20WL2, Q5JZ96, Q8IUY8, Q8TEM8, B0QYD0,
UniProt Related Accession:Q8NET5
Molecular Weight:29,686 Da
NCBI Full Name:NFAT activation molecule 1 isoform 1
NCBI Synonym Full Names:NFAT activating protein with ITAM motif 1
NCBI Official Symbol:NFAM1  
NCBI Official Synonym Symbols:CNAIP  
NCBI Protein Information:NFAT activation molecule 1
UniProt Protein Name:NFAT activation molecule 1
UniProt Synonym Protein Names:Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1
Protein Family:NFAT activation molecule
UniProt Gene Name:NFAM1  
UniProt Entry Name:NFAM1_HUMAN
Anti-NFAM1 Antibody (CAB15570)Western blot analysis of extracts of Mouse spleen, using NFAM1 antibody (CAB15570) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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