Name: Anti-NEUROG3 Antibody (CAB16526)
Brand: Developmental Biology
SKU: CAB16526
Availability: OutOfStock

Antibody Name:	Anti-NEUROG3 Antibody
Antibody SKU:	CAB16526
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human NEUROG3 (NP_066279.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Rat large intestine

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human NEUROG3 (NP_066279.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MTPQ PSGA PTVQ VTRE TERS FPRA SEDE VTCP TSAP PSPT RTRG NCAE AEEG GCRG APRK LRAR RGGR SRPK SELA LSKQ RRS
Gene ID:	50674
Uniprot:	Q9Y4Z2
Cellular Location:	Nucleus
Calculated MW:	23kDa
Observed MW:	30KDa

Synonyms:	NEUROG3, Atoh5, Math4B, NGN-3, bHLHa7, ngn3
Background:	The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).

UniProt Protein Function:	neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
UniProt Protein Details:	Protein type:Cell development/differentiation; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein dimerization activity; chromatin DNA binding; double-stranded DNA binding; transcription coactivator activity Biological Process: nervous system development; central nervous system development; transcription, DNA-dependent; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; peripheral nervous system development; epithelial cell differentiation; spinal cord development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; hindbrain development Disease: Diarrhea 4, Malabsorptive, Congenital
NCBI Summary:	The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
UniProt Code:	Q9Y4Z2
NCBI GenInfo Identifier:	229462908
NCBI Gene ID:	50674
NCBI Accession:	Q9Y4Z2.2
UniProt Secondary Accession:	Q9Y4Z2,Q5VVI0, Q6DJX6, Q9BY24,
UniProt Related Accession:	Q9Y4Z2
Molecular Weight:	214
NCBI Full Name:	Neurogenin-3
NCBI Synonym Full Names:	neurogenin 3
NCBI Official Symbol:	NEUROG3
NCBI Official Synonym Symbols:	ngn3; Atoh5; NGN-3; Math4B; bHLHa7
NCBI Protein Information:	neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7
UniProt Protein Name:	Neurogenin-3
UniProt Synonym Protein Names:	Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5
UniProt Gene Name:	NEUROG3
UniProt Entry Name:	NGN3_HUMAN

Western blot analysis of extracts of Rat large intestine, using NEUROG3 antibody (CAB16526) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s.

Antibodies

Anti-NEUROG3 Antibody (CAB2772)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)