Anti-Neuregulin-3 (NRG3) Antibody (CAB19763)

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SKU:
CAB19763
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HRG3
Synonyms:
pro-NRG3

Description

Product Name:Neuregulin-3 (NRG3) Rabbit mAb
Product Code:CAB19763
Size:20uL, 50uL, 100uL
Synonyms:HRG3, pro-NRG3
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Neuregulin-3 (Neuregulin-3 (NRG3))
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, U-251MG, C6, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human Neuregulin-3 (Neuregulin-3 (NRG3))
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10718
Uniprot:P56975
Calculated MW:56kDa
Observed MW:56KDa
UniProt Protein Function:NRG3: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Belongs to the neuregulin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 10q23.1

Cellular Component: extracellular region; extracellular space; integral to plasma membrane; intracellular

Molecular Function:chemorepellent activity; growth factor activity; receptor binding; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activator activity

Biological Process: chemorepulsion involved in interneuron migration from the subpallium to the cortex; organ development; pattern specification process; regulation of cell growth; transmembrane receptor protein tyrosine kinase activation (dimerization)

NCBI Summary:This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
UniProt Code:P56975
NCBI GenInfo Identifier:9789758
NCBI Gene ID:10718
NCBI Accession:P56975.1
UniProt Secondary Accession:P56975,Q0PEH2, Q5VYH3, A4D7U1,
UniProt Related Accession:P56975
Molecular Weight:75,031 Da
NCBI Full Name:Pro-neuregulin-3, membrane-bound isoform
NCBI Synonym Full Names:neuregulin 3
NCBI Official Symbol:NRG3  
NCBI Official Synonym Symbols:HRG3; pro-NRG3  
NCBI Protein Information:pro-neuregulin-3, membrane-bound isoform
UniProt Protein Name:Pro-neuregulin-3, membrane-bound isoform
Protein Family:Pro-neuregulin
UniProt Gene Name:NRG3  
UniProt Entry Name:NRG3_HUMAN
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