Cell Biology Antibodies 17
Anti-NEFH Antibody (CAB19084)
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- SKU:
- CAB19084
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NEFH Antibody |
| Antibody SKU: | CAB19084 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NEFH |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain, HT-29, PC-3 |
| Immunogen: | A synthesized peptide derived from human NEFH |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4744 |
| Uniprot: | P12036 |
| Cellular Location: | |
| Calculated MW: | 200kDa |
| Observed MW: | 65kDa/220kDa |
 | Western blot - NEFH Rabbit mAb (CAB19084) |
| Synonyms: | CMT2CC, NFH, NEFH |
| Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008] |
| UniProt Protein Function: | NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: mitochondrion; axon; cytoplasm; neurofilament Molecular Function:protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis Disease: Amyotrophic Lateral Sclerosis 1 |
| NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P12036 |
| NCBI GenInfo Identifier: | 226726294 |
| NCBI Gene ID: | 4744 |
| NCBI Accession: | P12036.4 |
| UniProt Secondary Accession: | P12036,Q96HF8, Q9UJS7, Q9UQ14, B4DYY4, |
| UniProt Related Accession: | P12036 |
| Molecular Weight: | |
| NCBI Full Name: | Neurofilament heavy polypeptide |
| NCBI Synonym Full Names: | neurofilament, heavy polypeptide |
| NCBI Official Symbol: | NEFH |
| NCBI Official Synonym Symbols: | NFH |
| NCBI Protein Information: | neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa |
| UniProt Protein Name: | Neurofilament heavy polypeptide |
| UniProt Synonym Protein Names: | 200 kDa neurofilament protein; Neurofilament triplet H protein |
| Protein Family: | Neurofilament heavy polypeptide |
| UniProt Gene Name: | NEFH |
| UniProt Entry Name: | NFH_HUMAN |
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