Cell Biology Antibodies 17

Anti-NEFH Antibody (CAB19084)

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SKU:
CAB19084
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NEFH Antibody
Antibody SKU:CAB19084
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human NEFH
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain, HT-29, PC-3
Immunogen:A synthesized peptide derived from human NEFH
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4744
Uniprot:P12036
Cellular Location:
Calculated MW:200kDa
Observed MW:65kDa/220kDa
Anti-NEFH Antibody (CAB19084)Western blot - NEFH Rabbit mAb (CAB19084)
Synonyms:CMT2CC, NFH, NEFH
Background:Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
UniProt Protein Function:NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrion; axon; cytoplasm; neurofilament

Molecular Function:protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding

Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis

Disease: Amyotrophic Lateral Sclerosis 1

NCBI Summary:Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
UniProt Code:P12036
NCBI GenInfo Identifier:226726294
NCBI Gene ID:4744
NCBI Accession:P12036.4
UniProt Secondary Accession:P12036,Q96HF8, Q9UJS7, Q9UQ14, B4DYY4,
UniProt Related Accession:P12036
Molecular Weight:
NCBI Full Name:Neurofilament heavy polypeptide
NCBI Synonym Full Names:neurofilament, heavy polypeptide
NCBI Official Symbol:NEFH  
NCBI Official Synonym Symbols:NFH  
NCBI Protein Information:neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa
UniProt Protein Name:Neurofilament heavy polypeptide
UniProt Synonym Protein Names:200 kDa neurofilament protein; Neurofilament triplet H protein
Protein Family:Neurofilament heavy polypeptide
UniProt Gene Name:NEFH  
UniProt Entry Name:NFH_HUMAN
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