Immunology Antibodies 3
Anti-NEDD4 Antibody (CAB4385)
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- SKU:
- CAB4385
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NEDD4-1
- Synonyms:
- RPF1
- Research Area:
- Immunology
Description
| Product Name: | NEDD4 Rabbit mAb |
| Product Code: | CAB4385 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NEDD4-1, RPF1 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NEDD4 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human NEDD4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4734 |
| Uniprot: | P46934 |
| Calculated MW: | 135kDa |
| Observed MW: | 120KDa |
| UniProt Protein Function: | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). |
| UniProt Code: | P46934 |
| NCBI GenInfo Identifier: | 313104311 |
| NCBI Gene ID: | 4734 |
| NCBI Accession: | P46934.4 |
| UniProt Secondary Accession: | P46934,A1KY35, A6ND72, A7MD29, B4E2R7, B7ZM59, B7ZM60 B9EGN5, D6RF89, |
| UniProt Related Accession: | P46934 |
| Molecular Weight: | 1319 |
| NCBI Full Name: | E3 ubiquitin-protein ligase NEDD4 |
| NCBI Synonym Full Names: | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | NEDD4 |
| NCBI Official Synonym Symbols: | RPF1; NEDD4-1 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase NEDD4; receptor-potentiating factor 1; cell proliferation-inducing gene 53 protein; neural precursor cell expressed developmentally down-regulated protein 4 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase NEDD4 |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 53 protein; Neural precursor cell expressed developmentally down-regulated protein 4; NEDD-4 |
| Protein Family: | Nedd4 binding protein |
| UniProt Gene Name: | NEDD4 |
| UniProt Entry Name: | NEDD4_HUMAN |
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