Anti-NDUFS4 Antibody (CAB8691)
- SKU:
- CAB8691
Description
| Product Name: | NDUFS4 Rabbit mAb |
| Product Code: | CAB8691 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AQDQ, CI-18, CI-18 kDa, CI-AQDQ |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NDUFS4 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Rat brain, Rat kidney, Rat heart, HepG2 |
| Immunogen: | A synthesized peptide derived from human NDUFS4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4724 |
| Uniprot: | O43181 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Calculated MW: | 18kDa |
| Observed MW: | 19kDa |
| UniProt Protein Function: | NDUFS4: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I NDUFS4 subunit family. |
| UniProt Protein Details: | Protein type:EC 1.6.99.3; Oxidoreductase; EC 1.6.5.3; Mitochondrial; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 5q11.1 Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex I Molecular Function:NADH dehydrogenase (ubiquinone) activity Biological Process: mitochondrial respiratory chain complex I assembly; cellular metabolic process; regulation of protein amino acid phosphorylation; cAMP-mediated signaling; positive regulation of fibroblast proliferation; response to cAMP; mitochondrial electron transport, NADH to ubiquinone; cellular respiration; brain development Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency |
| NCBI Summary: | This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43181 |
| NCBI GenInfo Identifier: | 3287881 |
| NCBI Gene ID: | 4724 |
| NCBI Accession: | O43181.1 |
| UniProt Secondary Accession: | O43181,Q9BS69, |
| UniProt Related Accession: | O43181 |
| Molecular Weight: | 175 |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) |
| NCBI Official Symbol: | NDUFS4 |
| NCBI Official Synonym Symbols: | AQDQ; CI-18 |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-AQDQ; CI-18 kDa; complex I-AQDQ; complex I-18 kDa; complex I 18kDa subunit; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; mitochondrial respiratory chain complex I (18-KD subunit) |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial |
| UniProt Synonym Protein Names: | Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit |
| Protein Family: | NADH dehydrogenase [ubiquinone] iron-sulfur protein |
| UniProt Gene Name: | NDUFS4 |
| UniProt Entry Name: | NDUS4_HUMAN |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Synonyms: |
AQDQ |
Synonyms: |
CI-18 |
Synonyms: |
CI-18 kDa |
Synonyms: |
CI-AQDQ |
Research Area: |
Cell Biology |
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