Epigenetics & Nuclear Signaling Antibodies 4
Anti-NCOR2 Antibody (CAB8388)
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- SKU:
- CAB8388
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NCOR2 Antibody |
| Antibody SKU: | CAB8388 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 670-900 of human NCOR2 (NP_006303.4). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 670-900 of human NCOR2 (NP_006303.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KLKM EKER NARR KKKK APAA ASEE AAFP PVVE DEEM EASG VSGN EEEM VEEA EALH ASGN EVPR GECS GPAT VNNS SDTE SIPS PHTE AAKD TGQN GPKP PATL GADG PPPG PPTP PPED IPAP TEPT PASE ATGA PTPP PAPP SPSA PPPV VPKE EKEE ETAA APPV EEGE EQKP PAAE ELAV DTGK AEEP VKSE CTEE AEEG PAKG KDAE AAEA TAEG ALKA EKKE GGS |
| Gene ID: | 9612 |
| Uniprot: | Q9Y618 |
| Cellular Location: | Nucleus |
| Calculated MW: | 81kDa/268kDa/273kDa/274kDa |
| Observed MW: | 275kDa |
| Synonyms: | NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1 |
| Background: | This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. |
| NCBI Summary: | This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011] |
| UniProt Code: | Q9Y618 |
| NCBI GenInfo Identifier: | 226713806 |
| NCBI Gene ID: | 9612 |
| NCBI Accession: | Q9Y618.2 |
| UniProt Secondary Accession: | Q9Y618,O00613, O15416, O15421, Q13354, Q56D06, Q59GM0 Q9Y5U0, |
| UniProt Related Accession: | Q9Y618 |
| Molecular Weight: | |
| NCBI Full Name: | Nuclear receptor corepressor 2 |
| NCBI Synonym Full Names: | nuclear receptor corepressor 2 |
| NCBI Official Symbol: | NCOR2 |
| NCBI Official Synonym Symbols: | SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau |
| NCBI Protein Information: | nuclear receptor corepressor 2 |
| UniProt Protein Name: | Nuclear receptor corepressor 2 |
| UniProt Synonym Protein Names: | CTG repeat protein 26; SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor |
| Protein Family: | Nuclear receptor corepressor |
| UniProt Gene Name: | NCOR2 |
| UniProt Entry Name: | NCOR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NCOR2 antibody (CAB8388) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Immunohistochemistry of paraffin-embedded rat spleen using NCOR2 Rabbit pAb (CAB8388) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using NCOR2 Rabbit pAb (CAB8388) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NCOR2 Rabbit pAb (CAB8388) at dilution of 1:100 (40x lens). |
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