Cell Cycle Antibodies 1
Anti-NCAPH Antibody (CAB15141)
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- SKU:
- CAB15141
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-NCAPH Antibody |
| Antibody SKU: | CAB15141 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NCAPH (NP_056156.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NCAPH (NP_056156.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGPP GPAL PATM NNSS SETR GHPH SASS PSER VFPM PLPR KAPL NIPG TPVL EDFP QNDD EKER LQRR RSRV FDLQ FSTD SPRL LASP SSRS IDIS ATIP KFTN TQIT EHYS TCIK LSTE NKIT TKNA FGLH LIDF MSEI LKQK DTEP TNFK VAAG TLDA STKI YAVR VDAV HADV YRVL GGLG KDAP SLEE VEGH VADG SATE MGTT KKAV KPKK KHLH RTIE QNIN NLNV SEAD RKCE IDPM FQKT AA |
| Gene ID: | 23397 |
| Uniprot: | Q15003 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus |
| Calculated MW: | 67kDa/82kDa |
| Observed MW: |
| Synonyms: | NCAPH, BRRN1, CAP-H |
| Background: | This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. |
| UniProt Protein Function: | NCAPH: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the CND2 (condensin subunit 2) family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 2q11.2 Cellular Component: condensin complex; cytosol; membrane Molecular Function:protein binding Biological Process: mitotic chromosome condensation |
| NCBI Summary: | This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q15003 |
| NCBI GenInfo Identifier: | 116241306 |
| NCBI Gene ID: | 23397 |
| NCBI Accession: | Q15003.3 |
| UniProt Secondary Accession: | Q15003,Q8TB87, B4E189, |
| UniProt Related Accession: | Q15003 |
| Molecular Weight: | 67,495 Da |
| NCBI Full Name: | Condensin complex subunit 2 |
| NCBI Synonym Full Names: | non-SMC condensin I complex subunit H |
| NCBI Official Symbol: | NCAPH |
| NCBI Official Synonym Symbols: | BRRN1; CAP-H |
| NCBI Protein Information: | condensin complex subunit 2 |
| UniProt Protein Name: | Condensin complex subunit 2 |
| UniProt Synonym Protein Names: | Barren homolog protein 1; Chromosome-associated protein H; hCAP-H; Non-SMC condensin I complex subunit H; XCAP-H homolog |
| Protein Family: | Condensin complex |
| UniProt Gene Name: | NCAPH |
| UniProt Entry Name: | CND2_HUMAN |
 | Immunofluorescence analysis of U2OS cells using NCAPH antibody (CAB15141) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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