Cell Biology Antibodies 15
Anti-NANOS2 Antibody (CAB17926)
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- SKU:
- CAB17926
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NANOS2 Antibody |
| Antibody SKU: | CAB17926 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human NANOS2 (NP_001025032.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human NANOS2 (NP_001025032.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQLP PFDM WKDY FNLS QVVW ALIA SRGQ RLET QEIE EPSP GPPL GQDQ GLGA PGAN GGLG TLCN FCKH NGES RHVY SSHQ LKTP DGVV VCPI LRHY VCPV CGAT GDQA HTLK YCPL NGGQ QSLY RRSG RNSA GRRV KR |
| Gene ID: | 339345 |
| Uniprot: | P60321 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NOS2, ZC2HC12B, NANOS2 |
| Background: |
| UniProt Protein Function: | NANOS2: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. Belongs to the nanos family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus Molecular Function:mRNA binding; protein binding; zinc ion binding Biological Process: multicellular organismal development; negative regulation of translation; negative regulation of meiosis; mRNA catabolic process; spermatogenesis; germ-line stem cell maintenance |
| UniProt Code: | P60321 |
| NCBI GenInfo Identifier: | 41688561 |
| NCBI Gene ID: | 339345 |
| NCBI Accession: | P60321.1 |
| UniProt Related Accession: | P60321 |
| Molecular Weight: | |
| NCBI Full Name: | Nanos homolog 2 |
| NCBI Synonym Full Names: | nanos C2HC-type zinc finger 2 |
| NCBI Official Symbol: | NANOS2 |
| NCBI Official Synonym Symbols: | NOS2; ZC2HC12B |
| NCBI Protein Information: | nanos homolog 2 |
| UniProt Protein Name: | Nanos homolog 2 |
| UniProt Gene Name: | NANOS2 |
| UniProt Entry Name: | NANO2_HUMAN |
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