Cell Biology Antibodies 17
Anti-MYH11 Antibody (CAB4064)
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- SKU:
- CAB4064
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MYH11 Antibody |
| Antibody SKU: | CAB4064 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MYH11 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat lung |
| Immunogen: | A synthesized peptide derived from human MYH11 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4629 |
| Uniprot: | P35749 |
| Cellular Location: | |
| Calculated MW: | 250kDa |
| Observed MW: | 250KDa |
| Synonyms: | AAT4, FAA4, SMHC, SMMHC |
| Background: | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | MYH11: Muscle contraction. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4); also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Oncoprotein; Motor Chromosomal Location of Human Ortholog: 16p13.11 Cellular Component: smooth muscle contractile fiber; melanosome; stress fiber; muscle myosin complex; cytosol Molecular Function:calmodulin binding; actin filament binding; protein binding; structural constituent of muscle; motor activity; ATP binding Biological Process: muscle thick filament assembly; elastic fiber assembly; axon guidance; smooth muscle contraction; muscle contraction; metabolic process; cardiac muscle fiber development; ephrin receptor signaling pathway Disease: Aortic Aneurysm, Familial Thoracic 4 |
| NCBI Summary: | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35749 |
| NCBI GenInfo Identifier: | 13432177 |
| NCBI Gene ID: | 4629 |
| NCBI Accession: | P35749.3 |
| UniProt Secondary Accession: | P35749,O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1 D2JYH7, |
| UniProt Related Accession: | P35749 |
| Molecular Weight: | 1972 |
| NCBI Full Name: | Myosin-11 |
| NCBI Synonym Full Names: | myosin, heavy chain 11, smooth muscle |
| NCBI Official Symbol: | MYH11 |
| NCBI Official Synonym Symbols: | AAT4; FAA4; SMHC; SMMHC |
| NCBI Protein Information: | myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; myosin, heavy polypeptide 11, smooth muscle |
| UniProt Protein Name: | Myosin-11 |
| UniProt Synonym Protein Names: | Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC |
| Protein Family: | Myosin |
| UniProt Gene Name: | MYH11 |
| UniProt Entry Name: | MYH11_HUMAN |
 | Western blot - MYH11 Rabbit mAb (CAB4064) |
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