Epigenetics & Nuclear Signaling Antibodies 3
Anti-MYCBP Antibody (CAB4623)
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- SKU:
- CAB4623
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MYCBP
- Synonyms:
- AMY-1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | MYCBP Rabbit pAb |
| Product Code: | CAB4623 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MYCBP, AMY-1 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human MYCBP (NP_036465.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | A-549, K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human MYCBP (NP_036465.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAHY KAAD SKRE QFRR YLEK SGVL DTLT KVLV ALYE EPEK PNSA LDFL KHHL GAAT PENP EIEL LRLE LAEM KEKY EAIV EENK KLKA KLAQ YEPP QEEK RAE |
| Gene ID: | 26292 |
| Uniprot: | Q99417 |
| Cellular Location: | Cytoplasm, Mitochondrion, Nucleus |
| Calculated MW: | 11kDa |
| Observed MW: | 12kDa |
| UniProt Protein Function: | MYCBP: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC. Belongs to the AMY1 family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p33-p32.2 Cellular Component: centrosome; mitochondrion; cytoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spermatogenesis |
| NCBI Summary: | The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q99417 |
| NCBI GenInfo Identifier: | 33112671 |
| NCBI Gene ID: | 26292 |
| NCBI Accession: | Q99417.3 |
| UniProt Secondary Accession: | Q99417,Q5TA64, Q96HE2, B2R4N0, |
| UniProt Related Accession: | Q99417 |
| Molecular Weight: | 103 |
| NCBI Full Name: | C-Myc-binding protein |
| NCBI Synonym Full Names: | MYC binding protein |
| NCBI Official Symbol: | MYCBP |
| NCBI Official Synonym Symbols: | AMY-1 |
| NCBI Protein Information: | C-Myc-binding protein; associate of myc-1; c-myc binding protein |
| UniProt Protein Name: | C-Myc-binding protein |
| UniProt Synonym Protein Names: | Associate of Myc 1; AMY-1 |
| Protein Family: | MYCBP-associated protein |
| UniProt Gene Name: | MYCBP |
| UniProt Entry Name: | MYCBP_HUMAN |
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