Epigenetics & Nuclear Signaling Antibodies 3
Anti-MXD1 Antibody (CAB3613)
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- SKU:
- CAB3613
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MXD1 Antibody |
| Antibody SKU: | CAB3613 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human MXD1 (NP_002348.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human MXD1 (NP_002348.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA VRMN IQML LEAA DYLE RRER EAEH GYAS MLPY NNKD RDAL KRRN KSKK NNSS SRST HNEM EKNR RAHL RLCL EKLK GLVP LGPE SSRH TTLS LLTK AKLH IKKL EDCD RKAV HQID QLQR EQRH LKRQ LEKL GIER IRMD SIGS TVSS ERSD SDRE EIDV DVES TDYL TGDL DWSS SSVS DSDE RGSM QSLG SDEG YSST SIKR IKLQ DSHK ACLG L |
| Gene ID: | 4084 |
| Uniprot: | Q05195 |
| Cellular Location: | Nucleus |
| Calculated MW: | 24kDa/25kDa |
| Observed MW: | 30kDa |
| Synonyms: | MXD1, BHLHC58, MAD, MAD1 |
| Background: | This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | Mad1: Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: nucleus Molecular Function:protein dimerization activity; transcription cofactor activity; transcription corepressor activity; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q05195 |
| NCBI GenInfo Identifier: | 729978 |
| NCBI Gene ID: | 4084 |
| NCBI Accession: | Q05195.1 |
| UniProt Secondary Accession: | Q05195,Q6FI41, B2R6V8, B7ZLI6, D6W5G2, |
| UniProt Related Accession: | Q05195 |
| Molecular Weight: | 221 |
| NCBI Full Name: | Max dimerization protein 1 |
| NCBI Synonym Full Names: | MAX dimerization protein 1 |
| NCBI Official Symbol: | MXD1 |
| NCBI Official Synonym Symbols: | MAD; MAD1; BHLHC58 |
| NCBI Protein Information: | max dimerization protein 1; max dimerizer 1; MAX-binding protein; antagonizer of myc transcriptional activity |
| UniProt Protein Name: | Max dimerization protein 1 |
| UniProt Synonym Protein Names: | Protein MAD |
| Protein Family: | Max dimerization protein |
| UniProt Gene Name: | MXD1 |
| UniProt Entry Name: | MAD1_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using MXD1 antibody (CAB3613) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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