Anti-MVP Antibody (CAB1039)
- SKU:
- CAB1039
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LRP
- Synonyms:
- VAULT1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | MVP Rabbit mAb |
| Product Code: | CAB1039 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | LRP, VAULT1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MVP |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, A-549, Mouse lung, Mouse liver, Rat lung, Rat kidney |
| Immunogen: | A synthesized peptide derived from human MVP |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9961 |
| Uniprot: | Q14764 |
| Cellular Location: | Cytoplasm, Nucleus, nuclear pore complex |
| Calculated MW: | 99kDa |
| Observed MW: | 100kDa |
| UniProt Protein Function: | MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; nucleus; ribonucleoprotein complex Molecular Function:protein binding; protein phosphatase binding; protein kinase binding Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation |
| NCBI Summary: | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | Q14764 |
| NCBI GenInfo Identifier: | 21542417 |
| NCBI Gene ID: | 9961 |
| NCBI Accession: | Q14764.4 |
| UniProt Secondary Accession: | Q14764,Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1, |
| UniProt Related Accession: | Q14764 |
| Molecular Weight: | 893 |
| NCBI Full Name: | Major vault protein |
| NCBI Synonym Full Names: | major vault protein |
| NCBI Official Symbol: | MVP |
| NCBI Official Synonym Symbols: | LRP; VAULT1 |
| NCBI Protein Information: | major vault protein; lung resistance-related protein |
| UniProt Protein Name: | Major vault protein |
| UniProt Synonym Protein Names: | Lung resistance-related protein |
| Protein Family: | Hyperpolarization-activated voltage-gated potassium channel |
| UniProt Gene Name: | MVP |
| UniProt Entry Name: | MVP_HUMAN |
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