Developmental Biology
Anti-MUSK Antibody (CAB2591)
- SKU:
- CAB2591
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Antibody Name: | Anti-MUSK Antibody |
| Antibody SKU: | CAB2591 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 424-783 of human MUSK (NP_001159752.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 424-783 of human MUSK (NP_001159752.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTIT TLYC CRRR KQWK NKKR ESAA VTLT TLPS ELLL DRLH PNPM YQRM PLLL NPKL LSLE YPRN NIEY VRDI GEGA FGRV FQAR APGL LPYE PFTM VAVK MLKE EASA DMQA DFQR EAAL MAEF DNPN IVKL LGVC AVGK PMCL LFEY MAYG DLNE FLRS MSPH TVCS LSHS DLSM RAQV SSPG PPPL SCAE QLCI ARQV AAGM AYLS ERKF VHRD LATR NCLV GENM VVKI ADFG LSRN IYSA DYYK ANEN DAIP IRWM PPES IFYN RYTT ESDV WAYG VVLW EIFS YGLQ PYYG MAHE EVIY YVRD GNIL SCPE NCPV ELYN LMRL CWSK LPAD RPSF TSIH RILE RMCE RAEG TVSV |
| Gene ID: | 4593 |
| Uniprot: | O15146 |
| Cellular Location: | Cell junction, Single-pass type I membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 86kDa/87kDa/97kDa |
| Observed MW: | 97kDa |
| Synonyms: | MUSK, CMS9, FADS |
| Background: | This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity. |
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Musk family Chromosomal Location of Human Ortholog: 9q31.3-q32 Cellular Component: postsynaptic membrane; integral to plasma membrane; neuromuscular junction; cell junction; receptor complex Molecular Function:protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; multicellular organismal development; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; memory; neuromuscular junction development Disease: Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency; Fetal Akinesia Deformation Sequence |
| NCBI Summary: | This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] |
| UniProt Code: | O15146 |
| NCBI GenInfo Identifier: | 50400806 |
| NCBI Gene ID: | 4593 |
| NCBI Accession: | O15146.1 |
| UniProt Secondary Accession: | O15146,Q32MJ8, Q32MJ9, Q5VZW7, Q5VZW8, |
| UniProt Related Accession: | O15146 |
| Molecular Weight: | 86,425 Da |
| NCBI Full Name: | Muscle, skeletal receptor tyrosine-protein kinase |
| NCBI Synonym Full Names: | muscle, skeletal, receptor tyrosine kinase |
| NCBI Official Symbol: | MUSK |
| NCBI Protein Information: | muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor |
| UniProt Protein Name: | Muscle, skeletal receptor tyrosine-protein kinase |
| UniProt Synonym Protein Names: | Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor |
| Protein Family: | Muskelin |
| UniProt Gene Name: | MUSK |
| UniProt Entry Name: | MUSK_HUMAN |
 | Western blot analysis of extracts of SW480 cells, using MUSK antibody (CAB2591) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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