Cell Biology Antibodies 2

Anti-MTSS1 Antibody (CAB11697)

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SKU:
CAB11697
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MTSS1 Antibody
Antibody SKU:CAB11697
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_055566.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HT-29, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_055566.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPAP PDGP EERG EHSP ESPS VGEG PQGV TSMP SSMW SGQA SVNP PLPG PKPS IPEE HRQA IPES EAED QERE PPSA TVSP GQIP ESDP ADLS PRDT PQGE D
Gene ID:9788
Uniprot:O43312
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:50kDa/79kDa/82kDa
Observed MW:115kDa
Synonyms:MTSS1, MIM, MIMA, MIMB
Background:
UniProt Protein Function:MTSS1: an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: actin cytoskeleton; cytoplasm; endocytic vesicle

Molecular Function:actin monomer binding; identical protein binding; protein binding; receptor binding

Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:O43312
NCBI GenInfo Identifier:30923156
NCBI Gene ID:9788
NCBI Accession:O43312.2
UniProt Secondary Accession:O43312,Q8TCA2, Q96RX2, J3KNK6,
UniProt Related Accession:O43312
Molecular Weight:82kDa
NCBI Full Name:Metastasis suppressor protein 1
NCBI Synonym Full Names:MTSS1, I-BAR domain containing
NCBI Official Symbol:MTSS1  
NCBI Official Synonym Symbols:MIM; MIMA; MIMB  
NCBI Protein Information:metastasis suppressor protein 1
UniProt Protein Name:Metastasis suppressor protein 1
UniProt Synonym Protein Names:Metastasis suppressor YGL-1; Missing in metastasis protein
Protein Family:MTSS1-like protein
UniProt Gene Name:MTSS1  
Anti-MTSS1 Antibody (CAB11697)Western blot analysis of extracts of various cell lines, using MTSS1 antibody (CAB11697) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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system_update_altDatasheetHuman MTSS1 Recombinant Protein MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. M