Cell Biology Antibodies 2
Anti-MTCO2 Antibody (CAB11522)
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- SKU:
- CAB11522
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MTCO2 Antibody |
| Antibody SKU: | CAB11522 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse MTCO2 (NP_904331.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Mouse kidney, Rat liver, Rat kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse MTCO2 (NP_904331.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGHQ WYWS YEYT DYED LCFD SYMI PTND LKPG ELRL LEVD NRVV LPME LPIR MLIS SEDV LHSW AVPS LGLK TDAI PGRL NQAT VTSN RPGL FYGQ CSEI C |
| Gene ID: | 17709 |
| Uniprot: | P00403 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 23kDa |
| Synonyms: | MT-CO2, COII, MTCO2, COX2 |
| Background: |
| UniProt Protein Function: | COX2: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1 Chromosomal Location of Human Ortholog: - Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes |
| UniProt Code: | P00403 |
| NCBI GenInfo Identifier: | 117020 |
| NCBI Gene ID: | |
| NCBI Accession: | P00403.1 |
| Molecular Weight: | |
| NCBI Full Name: | Cytochrome c oxidase subunit 2 |
| UniProt Protein Name: | Cytochrome c oxidase subunit 2 |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide II |
| UniProt Gene Name: | MT-CO2 |
| UniProt Entry Name: | COX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTCO2 antibody (CAB11522) at 1:800 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat lung using MTCO2 antibody (CAB11522) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using MTCO2 antibody (CAB11522) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using MTCO2 antibody (CAB11522) at dilution of 1:100 (40x lens). |
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