Cell Biology Antibodies 12
Anti-MRC1 Antibody (CAB8301)
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- SKU:
- CAB8301
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | MRC1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8301 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 610-860 of human MRC1 (NP_002429.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse lung, Rat liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 610-860 of human MRC1 (NP_002429.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLWD VLKC DEKA KFVC KHWA EGVT HPPK PTTT PEPK CPED WGAS SRTS LCFK LYAK GKHE KKTW FESR DFCR ALGG DLAS INNK EEQQ TIWR LITA SGSY HKLF WLGL TYGS PSEG FTWS DGSP VSYE NWAY GEPN NYQN VEYC GELK GDPT MSWN DINC EHLN NWIC QIQK GQTP KPEP TPAP QDNP PVTE DGWV IYKD YQYY FSKE KETM DNAR AFCK RNFG DLVS IQSE SEKK FLWK YVNR NDAQ SAY |
| Gene ID: | 4360 |
| Uniprot: | P22897 |
| Cellular Location: | Cell membrane, Endosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 56kDa/166kDa |
| Observed MW: | 166kDa |
| Synonyms: | MRC1, CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR |
| Background: | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. |
| UniProt Protein Function: | MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 10p12.33 Cellular Component: endosome membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding; receptor activity; transmembrane receptor activity Biological Process: receptor-mediated endocytosis |
| NCBI Summary: | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015] |
| UniProt Code: | P22897 |
| NCBI GenInfo Identifier: | 126730 |
| NCBI Gene ID: | 4360 |
| NCBI Accession: | P22897.1 |
| UniProt Secondary Accession: | P22897,Q5VSJ2, Q5VSK2, A5PKW3, |
| UniProt Related Accession: | P22897 |
| Molecular Weight: | 166kDa |
| NCBI Full Name: | Macrophage mannose receptor 1 |
| NCBI Synonym Full Names: | mannose receptor C-type 1 |
| NCBI Official Symbol: | MRC1 |
| NCBI Official Synonym Symbols: | MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1 |
| NCBI Protein Information: | macrophage mannose receptor 1 |
| UniProt Protein Name: | Macrophage mannose receptor 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206 |
| Protein Family: | Macrophage mannose receptor |
| UniProt Gene Name: | MRC1 |
 | Western blot analysis of extracts of various cell lines, using MRC1 antibody (CAB8301) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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