![Anti-Mouse CD120a (TNFR1) [55R-170] In Vivo Antibody - Low Endotoxin (IVMB0142)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/78788/83970/anti-mouse-cd120a-tnfr1-55r-170-in-vivo-antibody-low-endotoxin__20332__92842.1706545357.jpg?c=1?imbypass=on "Anti-Mouse CD120a (TNFR1) [55R-170] In Vivo Antibody - Low Endotoxin (IVMB0142)")
Description
| Product Name: | Anti-Mouse CD120a (TNFR1) [55R-170] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0142 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | 55R-170 |
| Protein: | TNFR1 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | CD120α, TNFRSF1A, P55, P60 |
| Isotype: | Armenian Hamster IgG |
| Reactivity: | Mouse |
| Immunogen: | Purified Recombinant Mouse TNFR1 (>98%) |
| Applications: | B, IP, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, IP, WB |
| Reactivity: | Mouse |
| Host Species: | Armenian Hamster |
| Specificity: | Clone 55R-170 recognizes mouse CD120a. |
| Antigen Distribution: | CD120a is constitutively expressed in most tissues. |
| Immunogen: | Purified Recombinant Mouse TNFR1 (>98%) |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-α and TNF-β (also known as LT-α). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.
| Datasheet: | View |
| Protein: | TNFR1 |
| Function: | Apoptosis, NF-κB activation, inflammation, tumor necrosis, cell differentiation |
| Ligand/Receptor: | TNF-α, LT-α (TNF-β) |
| Research Area: | Immunology, Innate Immunity |
| Armenian Hamster IgG Isotype Control | |
|---|---|
| Clone | PIP |
| Isotype | Armenian Hamster IgG |
| Endotoxin Level | Low Endotoxin |
![Anti-Mouse CD120a (TNFR1) [55R-170] In Vivo Antibody - Low Endotoxin (IVMB0142)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/78788/83970/anti-mouse-cd120a-tnfr1-55r-170-in-vivo-antibody-low-endotoxin__20332__92842.1706545357.jpg?c=1 "Anti-Mouse CD120a (TNFR1) [55R-170] In Vivo Antibody - Low Endotoxin (IVMB0142)")
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