Cell Biology Antibodies 1
Anti-MMP7 Antibody (CAB0695)
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- SKU:
- CAB0695
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MMP7 Antibody |
| Antibody SKU: | CAB0695 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-267 of human MMP7 (NP_002414.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, Rat uterus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-267 of human MMP7 (NP_002414.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPLP QEAG GMSE LQWE QAQD YLKR FYLY DSET KNAN SLEA KLKE MQKF FGLP ITGM LNSR VIEI MQKP RCGV PDVA EYSL FPNS PKWT SKVV TYRI VSYT RDLP HITV DRLV SKAL NMWG KEIP LHFR KVVW GTAD IMIG FARG AHGD SYPF DGPG NTLA HAFA PGTG LGGD AHFD EDER WTDG SSLG INFL YAAT HELG HSLG MGHS SDPN AVMY PTYG NGDP QNFK LSQD DIKG IQKL YGKR SNSR KK |
| Gene ID: | 4316 |
| Uniprot: | P09237 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 29kDa |
| Observed MW: | 26kDa/34kDa |
| Synonyms: | MMP7, MMP-7, MPSL1, PUMP-1 |
| Background: | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. |
| UniProt Protein Function: | MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Protease; EC 3.4.24.23 Chromosomal Location of Human Ortholog: 11q22.2 Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to Gram-positive bacterium; antibacterial peptide biosynthetic process; defense response to Gram-negative bacterium; proteolysis; antibacterial peptide secretion; regulation of cell proliferation |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09237 |
| NCBI GenInfo Identifier: | 116861 |
| NCBI Gene ID: | 4316 |
| NCBI Accession: | P09237.1 |
| UniProt Secondary Accession: | P09237,Q9BTK9, |
| UniProt Related Accession: | P09237 |
| Molecular Weight: | 29,677 Da |
| NCBI Full Name: | Matrilysin |
| NCBI Synonym Full Names: | matrix metallopeptidase 7 (matrilysin, uterine) |
| NCBI Official Symbol: | MMP7 |
| NCBI Official Synonym Symbols: | MMP-7; MPSL1; PUMP-1 |
| NCBI Protein Information: | matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine) |
| UniProt Protein Name: | Matrilysin |
| UniProt Synonym Protein Names: | Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase |
| Protein Family: | Matrilysin |
| UniProt Gene Name: | MMP7 |
| UniProt Entry Name: | MMP7_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using MMP7 antibody (CAB0695) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Western blot analysis of extracts of Rat uterus, using MMP7 antibody (CAB0695) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using MMP7 Rabbit pAb (CAB0695) at dilution of 1:150 (40x lens). |
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