Anti-MIB1/DIP1 Antibody (CAB3371)
- SKU:
- CAB3371
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DIP-1
- Synonyms:
- DIP1
- Synonyms:
- LVNC7
- Synonyms:
- MIB
- Synonyms:
- ZZANK2
- Synonyms:
- ZZZ6
Description
| Product Name: | MIB1/DIP1 Rabbit mAb |
| Product Code: | CAB3371 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MIB1/DIP1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, K-562, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human MIB1/DIP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 57534 |
| Uniprot: | Q86YT6 |
| Cellular Location: | Cell membrane, Cytoplasm, centriolar satellite, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 110kDa |
| Observed MW: | 110kDa |
| UniProt Protein Function: | MIB1: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ligase Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: centrosome; postsynaptic density; cytoplasm; plasma membrane; cytoplasmic vesicle; cytosol Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: blood vessel development; somitogenesis; negative regulation of neuron differentiation; Notch signaling pathway; in utero embryonic development; protein ubiquitination; positive regulation of endocytosis; endocytosis; heart looping; neural tube formation Disease: Left Ventricular Noncompaction 7 |
| NCBI Summary: | This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q86YT6 |
| NCBI GenInfo Identifier: | 30348954 |
| NCBI Gene ID: | 57534 |
| NCBI Accession: | NP_065825 |
| UniProt Secondary Accession: | Q86YT6,Q2TB37, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7 Q9P2M3, B0YJ38, |
| UniProt Related Accession: | Q86YT6 |
| Molecular Weight: | Predicted: 89; 102; 111 kDaObserved: 103 kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase MIB1 |
| NCBI Synonym Full Names: | mindbomb E3 ubiquitin protein ligase 1 |
| NCBI Official Symbol: | MIB1 |
| NCBI Official Synonym Symbols: | MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase MIB1; DAPK-interacting protein 1; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase MIB1 |
| UniProt Synonym Protein Names: | DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; Zinc finger ZZ type with ankyrin repeat domain protein 2 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | MIB1 |
| UniProt Entry Name: | MIB1_HUMAN |
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